User profiles for A. Onar-Thomas
 | Arzu Onar-ThomasProfessor of Biostatistics, St Jude Children's Research Hospital Verified email at stjude.org Cited by 10905 |
Novel mutations target distinct subgroups of medulloblastoma
…, J Ma, J Easton, B Vadodaria, A Onar-Thomas… - Nature, 2012 - nature.com
Medulloblastoma is a malignant childhood brain tumour comprising four discrete subgroups.
Here, to identify mutations that drive medulloblastoma, we sequenced the entire genomes …
Here, to identify mutations that drive medulloblastoma, we sequenced the entire genomes …
[HTML][HTML] Vismodegib exerts targeted efficacy against recurrent sonic hedgehog–subgroup medulloblastoma: results from phase II pediatric brain tumor consortium …
…, M Rusch, SJ Allen, A Onar-Thomas… - Journal of Clinical …, 2015 - ncbi.nlm.nih.gov
… Allen, Arzu Onar-Thomas, Clinton F. Stewart, Maryam Fouladi, James M. Boyett, David W. …
Allen, Arzu Onar-Thomas, James M. Boyett, Richard J. Gilbertson, Tom Curran, David W …
Allen, Arzu Onar-Thomas, James M. Boyett, Richard J. Gilbertson, Tom Curran, David W …
[HTML][HTML] Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma
…, SN Chi, NS da Silva, A Onar-Thomas… - Journal of clinical …, 2011 - ncbi.nlm.nih.gov
Purpose Long-term survival for children with diffuse intrinsic pontine glioma (DIPG) is less
than 10%, and new therapeutic targets are urgently required. We evaluated a large cohort of …
than 10%, and new therapeutic targets are urgently required. We evaluated a large cohort of …
Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre …
J Fangusaro, A Onar-Thomas, TY Poussaint… - The lancet …, 2019 - thelancet.com
Background Paediatric low-grade glioma is the most common CNS tumour of childhood.
Although overall survival is good, disease often recurs. No single universally accepted …
Although overall survival is good, disease often recurs. No single universally accepted …
[HTML][HTML] Processing speed, attention, and working memory after treatment for medulloblastoma: an international, prospective, and longitudinal study
SL Palmer, C Armstrong, A Onar-Thomas… - Journal of Clinical …, 2013 - ncbi.nlm.nih.gov
… Palmer, Carol Armstrong, Arzu Onar-Thomas, Shengjie Wu, Dana Wallace, Melanie J.
Bonner, Jane Schreiber, Michelle Swain, Lynn Chapieski, Donald Mabbott, Sarah Knight …
Bonner, Jane Schreiber, Michelle Swain, Lynn Chapieski, Donald Mabbott, Sarah Knight …
[HTML][HTML] Outcomes by clinical and molecular features in children with medulloblastoma treated with risk-adapted therapy: results of an international phase III trial …
RESULTS Three hundred thirty eligible patients with medulloblastoma were enrolled. Five-year
PFS was 83.2%(95% CI, 78.4 to 88.2) for average-risk patients (n= 227) and 58.7%(95% …
PFS was 83.2%(95% CI, 78.4 to 88.2) for average-risk patients (n= 227) and 58.7%(95% …
Unified rhombic lip origins of group 3 and group 4 medulloblastoma
Medulloblastoma, a malignant childhood cerebellar tumour, segregates molecularly into
biologically distinct subgroups, suggesting that a personalized approach to therapy would be …
biologically distinct subgroups, suggesting that a personalized approach to therapy would be …
Novel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas
…, DA Bax, D Carvalho, RM Reis, A Onar-Thomas… - Cancer research, 2013 - AACR
The outcome for children with high-grade gliomas (HGG) remains dismal, with a 2-year
survival rate of only 10% to 30%. Diffuse intrinsic pontine glioma (DIPG) comprise a subset of …
survival rate of only 10% to 30%. Diffuse intrinsic pontine glioma (DIPG) comprise a subset of …
[PDF][PDF] Histone H3. 3 K27M accelerates spontaneous brainstem glioma and drives restricted changes in bivalent gene expression
Diffuse intrinsic pontine gliomas (DIPGs) are incurable childhood brainstem tumors with
frequent histone H3 K27M mutations and recurrent alterations in PDGFRA and TP53. We …
frequent histone H3 K27M mutations and recurrent alterations in PDGFRA and TP53. We …
[PDF][PDF] Serial assessment of measurable residual disease in medulloblastoma liquid biopsies
Nearly one-third of children with medulloblastoma, a malignant embryonal tumor of the
cerebellum, succumb to their disease. Conventional response monitoring by imaging and …
cerebellum, succumb to their disease. Conventional response monitoring by imaging and …
