In the developing retina, multipotent neural progenitors undergo unidirectional differentiation
in a precise spatiotemporal order. Here we profile the epigenetic and transcriptional …

Increasing evidence suggests that patients with L2-HGA have a predisposition to cerebral
neoplasms. This may be related to the pathologic accumulation of L2-HG because high …

Ewing sarcoma (EWS) is a tumor of the bone and soft tissue that primarily affects adolescents
and young adults. With current therapies, 70% of patients with localized disease survive, …

Neuroblastoma is a pediatric cancer of the developing sympathoadrenal lineage. The tumors
are known to develop from the adrenal gland or paraspinal ganglia and have molecular …

High throughput omics approaches provide an unprecedented opportunity for dissecting
molecular mechanisms in cancer biology. Here we present deep profiling of whole proteome, …

Diverse cell types can be reprogrammed into pluripotent stem cells by ectopic expression of
Oct4 (Pou5f1), Klf4, Sox3, and Myc. Many of these induced pluripotent stem cells (iPSCs) …

Significant advances have been made over the past 25 years in our understanding of the
most common adult solid tumors such as breast, colon, lung and prostate cancer. Much less is …

Metrics for evaluating interruptive prescribing alerts have many limitations. Additional methods
are needed to identify opportunities to improve alerting systems and prevent alert fatigue. …

OBJECTIVES: Excessive alerts are a common concern associated with clinical decision
support systems that monitor drug-drug interactions (DDIs). To reduce the number of low-value …

The concept of indistinguishability is the key element in quantum statistics. But, are particles
really either indistinguishable or distinguishable? Most works begin with the premise that all …