Admission serum high mobility group box 1 (HMGB1) protein predicts delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage

S Hemmer, S Senger, CJ Griessenauer, A Simgen… - Neurosurgical …, 2022 - Springer
High mobility group box 1 protein (HMGB1) is a prototypical damage associated particle and
acts as a key player in aseptic inflammation. HMGB1 appears critical for the crosstalk of a …

Acute occlusions of dual-layer carotid stents after endovascular emergency treatment of tandem lesions

U Yilmaz, H Körner, R Mühl-Benninghaus, A Simgen… - Stroke, 2017 - Am Heart Assoc
Background and Purpose— A new generation of carotid artery stents that uses a second
micromesh layer to reduce embolic events during carotid artery stenting has recently been …

Neurocognitive status in patients with newly-diagnosed brain tumors in good neurological condition: the impact of tumor type, volume, and location

P Hendrix, E Hans, CJ Griessenauer, A Simgen… - Clinical Neurology and …, 2017 - Elsevier
Objective Neurocognitive function is of great importance in patients with brain tumors. Even
patients in good neurological condition may suffer from neurocognitive dysfunction that …

[HTML][HTML] Why we fail: mechanisms and co-factors of unsuccessful thrombectomy in acute ischemic stroke

DM Heider, A Simgen, G Wagenpfeil, P Dietrich… - Neurological …, 2020 - Springer
Purpose Mechanical thrombectomy (MT) is an effective treatment for patients suffering from
acute ischemic stroke. However, recanalization fails in about 16.5% of interventions. We …

Evaluation of a newly designed flow diverter for the treatment of intracranial aneurysms in an elastase-induced aneurysm model, in New Zealand white rabbits

A Simgen, D Ley, C Roth, U Yilmaz, H Körner… - Neuroradiology, 2014 - Springer
Introduction In this study, we analyzed angiographic and histologic aneurysm occlusion of a
newly designed flow-diverting device. Visibility and flexibility, as well as occlusions of side …

[HTML][HTML] The pCONUS HPC: 30-day and 180-day in vivo biocompatibility results

…, R Hannes, H Monstadt, A Simgen… - CardioVascular and …, 2019 - Springer
Background Endovascular stents are commonly used during neurointerventional procedures;
however, the concomitant use of dual anti-platelet treatment (DAPT) can limit their use. …

[HTML][HTML] Prospective study to assess the tissue response to HPC-coated p48 flow diverter stents compared to uncoated devices in the rabbit carotid artery model

…, R Hannes, H Monstadt, A Simgen… - European Radiology …, 2019 - Springer
Background Flow diverters (FDs) are widely used in the treatment of intracranial aneurysms,
but the required medication increases the risk of haemorrhagic complications and limits …

Endovascular treatment of unruptured intracranial aneurysms with flow diverters: A retrospective long-term single center analysis

A Simgen, C Roth, J Kulikovski… - The Neuroradiology …, 2023 - journals.sagepub.com
Purpose The introduction of flow diverters (FDs) in 2007 greatly enhanced the treatment of
intracranial aneurysms. Here, we present our long-term clinical experience in treating …

The Derivo embolization device, a second-generation flow diverter for the treatment of intracranial aneurysms, evaluated in an elastase-induced aneurysm model

…, YJ Kim, B Scheller, W Reith, A Simgen - Clinical …, 2017 - Springer
Purpose In recent years, flow diverters have provided a promising alternative to treat
complex intracranial aneurysms. In this study, we compare a second-generation flow-diverting …

Neurocognitive function surrounding the resection of frontal WHO grade I meningiomas: a prospective matched-control study

P Hendrix, E Hans, CJ Griessenauer, A Simgen… - World neurosurgery, 2017 - Elsevier
Objective Patients with intracranial meningiomas can experience neurocognitive dysfunctions
in specific cognitive domains depending on tumor location and size. The literature …