Tumor necrosis factor (TNF) is a soluble protein that causes damage to tumor cells but has
no effect on normal cells. Human TNF was purified to apparent homogeneity as a 17.3-…

Human microbiome research has shown commensal bacteria to be a major factor in both
wellness and disease pathogenesis. Interest in the microbiome has recently expanded beyond …

An understanding of the logic of odor perception requires a functional analysis of odor-evoked
patterns of activity in neural assemblies in the brain. We have developed a sensitive …

In the fruit fly, Drosophila, olfactory sensory neurons expressing a given receptor project to
spatially invariant loci in the antennal lobe to create a topographic map of receptor activation. …

All animals exhibit innate behaviours in response to specific sensory stimuli that are likely to
result from the activation of developmentally programmed neural circuits. Here we observe …

We have isolated the "complete" repertoire of genes encoding the odorant receptors in
Drosophila and employ these genes to provide a molecular description of the organization of the …

Mammalian cellsin vivofrequently express primary cilia. Although some fully differentiated cell
types rarely, if ever, express them, most do, indicating that they are regular cell organelles. …

BACKGROUND AND PURPOSE: The clinical outcome of acute necrotizing encephalopathy
of childhood (ANEC), an encephalopathy characterized by symmetrical involvement of the …

The mutagenic effect of hepatitis B (HBV) integration in predisposing risk to hepatocellular
carcinoma (HCC) remains elusive. In this study, we performed transcriptome sequencing of …

We report that eight heterozygous missense mutations in TUBB3, encoding the neuron-specific
β-tubulin isotype III, result in a spectrum of human nervous system disorders that we now …