Adult mammalian CNS neurons do not normally regenerate their severed axons. This failure
has been attributed to scar tissue and inhibitory molecules at the injury site that block the …

Transplants of fibroblasts genetically modified to express BDNF (Fb/BDNF) have been
shown to promote regeneration of rubrospinal axons and recovery of forelimb function when …

Concussive brain injury (CBI) accounts for approximately 75% of all brain-injured people in
the United States each year and is particularly prevalent in contact sports. Concussion is the …

Previously, we reported that, when clonal neural stem cells (NSCs) were transplanted into
brains of postnatal mice subjected to unilateral hypoxic–ischemic (HI) injury (optimally 3–7 …

Advances in medical and rehabilitative care now allow the 10–12,000 individuals who suffer
spinal cord injuries each year in the United States to lead productive lives of nearly normal …

Patients with incomplete spinal cord injuries can spontaneously recover motor function. Because
of this, phase I and II trials of invasive interventions for acute spinal cord injury will likely …

Encapsulation of cells has the potential to provide a protective barrier against host immune
cell interactions after grafting. Previously we have shown that alginate encapsulated BDNF-…

Dorsal root (DR) axons regenerate in the PNS but turn around or stop at the dorsal root entry
zone (DREZ), the entrance into the CNS. Earlier studies that relied on conventional tracing …

Blasts are responsible for about two-thirds of the combat injuries in Operation Iraqi Freedom
and Operation Enduring Freedom, which include at least 1,200 traumatic brain injuries. …

Recent advances in the isolation and characterization of neural precursor cells suggest that
they have properties that would make them useful transplants for the treatment of central …