BACKGROUND AND PURPOSE: Destructive lesions of the sinonasal tract, lacking a
discernible etiology and referred to as midline destructive disease, have been pathologically …

The differential diagnosis of a progressive destructive lesion of the midface and upper
airway region includes both neoplastic and non-neoplastic entities; of these, the majority of …

Background The aim of this study was to assess the principal signs and symptoms for severe
necrotizing midline nasal lesions and give diagnostic and management algorithms. Methods …

BACKGROUND: Midline destructive lesions (MDLs) of the nose are a diagnostic dilemma
due to an extensive differential diagnosis and vague presenting signs and symptoms …

Reports of sinonasal non-Hodgkin's lymphomas, analysed with monoclonal antibodies, are
scarce, and differentiation of these lymphomas from Wegener's granulomatosis can be …

Six cases were described in which an initial clinical diagnosis of “rhinitis gangrenosa
progressiva” or lethal midline granuloma was made. The histological examinations of their …

Advances in immunocytochemical phenotyping and molecular genetics have nearly
resolved the histopathologic and therapeutic quandaries brought about by a diagnostic …

Although differentiation of Wegener's granulomatosis from other destructive midline lesions
is now clearly recognized by clinicians and pathologists, confusion persists regarding the …

Midline Lethal granuloma is characterized by progressive destruction of nose, paranasal
sinuses and palate. Till date, the diagnosis of this mutilating process remains as enigma due …

A rare sight in clinical practice is the patient with ulceration and destruction of the midline
facial structures. A midfacial destructive process may manifest as a symptom of one of …