In 1971, Wang (1) discovered the first DNA topoisomerase in Escherichia coli. The enzyme (E.
coli DNA topoisomerase I, or w protein) catalyzed relaxation of negatively supercoiled …

A number of DNA minor groove-binding ligands (MGBLs) are known to exhibit antitumor
and antimicrobial activities. We show that DNA topoisomerase (Topo) I may be a …

Kaempferol is a polyphenol antioxidant found in fruits and vegetables. Many studies have
described the beneficial effects of dietary kaempferol in reducing the risk of chronic diseases, …

Hoechst dye 33342 (Ho33342), like many other DNA minor groove binding ligands and its
parent compound Hoechst dye 33258 (Ho33258), nonspecifically inhibits the catalytic …

Here, we use single-molecule techniques to study the aggregation of α-synuclein, the protein
whose misfolding and deposition is associated with Parkinson's disease. We identify a …

The breakage/reunion reaction of DNA topoisomerase II (TOP2) can be interrupted by DNA
intercalators (eg, doxorubicin), enzyme binders (eg, etoposide), or DNA lesions (eg, abasic …

Natural materials, such as bone, integrate living cells composed of organic molecules
together with inorganic components. This enables combinations of functionalities, such as …

The observations by Abraham et al.(1), that P-glycoprotein and the cystic fibrosis transmembrane
conductance regulator (CFTR) are associated with adenosine triphosphate (ATP) …

Immune checkpoint inhibitors (ICIs) are effective in the treatment of patients with advanced
cancer and have emerged as a pillar of standard cancer care. However, their use is …

In order to understand the high efficacy of camptothecin derivatives against human colon
tumor xenografts in nude mice, we have studied the transport properties of camptothecin …