Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily
in the midline of the central nervous system of young children, suggesting a cooperation …

Atypical teratoid rhabdoid tumors ( ATRT s) are recently defined highly aggressive embryonal
central nervous system tumors with a poor prognosis and no definitive guidelines for …

Background Median survival time of recurrent embryonal brain tumors is short regardless of
salvage chemotherapy used. An evolving alternative approach to conventional …

Purpose Bevacizumab (BEV) is approved in more than 60 countries for use in adults with
recurrent glioblastoma. We evaluated the addition of BEV to radiotherapy plus temozolomide (…

Background Neurofibromatosis type 1 (NF1) is a multisystem genetic disorder, predisposing
development of benign and malignant tumours. Given the oncogenic potential, long-term …

Purpose Neurofibromatosis type 1 (NF1) is characterized by a highly variable clinical
presentation, but almost all NF1-affected adults present with cutaneous and/or subcutaneous …

Low grade gliomas (LGGs) constitute the largest, yet clinically and (molecular-) histologically
heterogeneous group of pediatric brain tumors of WHO grades I and II occurring throughout …

The Ommaya reservoir facilitates repetitive delivery of drugs into the CSF and is a pharmacologically
rational system for intrathecal chemotherapy. Because previous studies have found …

Alveolar soft part sarcoma is a rare tumour of unknown histogenesis. Although tumour
growth is slow and often asymptomatic, vascular invasion and metastatic dissemination (…

Diffuse gliomas with K27M histone mutations (H3K27M glioma) are generally characterized
by a fatal prognosis, particularly affecting the pediatric population. Based on the molecular …