BACKGROUND AND PURPOSE: The mechanisms behind the demyelination that is
characteristic of multiple sclerosis (MS) are still poorly understood. The purpose of this study …

We used proton magnetic resonance (MR) spectroscopic imaging to determine the serial
changes in MR signals from choline, creatine, lactate, and N‐acetylaspartate in and around …

PURPOSE To elucidate the natural history of visualized MR abnormalities in patients with
multiple sclerosis using proton spectroscopy. METHODS MR imaging and proton …

Proton magnetic resonance spectroscopy (1H-MRS) provides tissue metabolic information
in vivo. This article reviews the role of MRS-determined metabolic alterations in lesions …

Serial magnetic resonnce (MR) studies that included proton MR spectroscopic imaging
(MRSI), contrast‐enhanced MR imaging (MRI), and lesion volumetric studies were …

Objective: To characterize and follow the diffuse gray and white matter (GM/WM) metabolic
abnormalities in early relapsing-remitting multiple sclerosis using proton magnetic …

BACKGROUND AND PURPOSE: Proton MR spectroscopy (1H-MR spectroscopy) is a well-
established method for the in vivo investigation of the normal-appearing white matter …

Magnetic resonance imaging (MRI) is widely used to evaluate and monitor disease activity
in inflammatory demyelinating central nervous system (CNS) diseases such as multiple …

Proton magnetic resonance spectroscopy (1H-MRS) investigation was performed on CSF
samples of patients with neurological inflammatory diseases including 53 cases of multiple …

Objective: To test the hypothesis that diffuse abnormalities precede axonal damage and
atrophy in the MRI normal-appearing tissue of relapsing-remitting (RR) multiple sclerosis …