With a 3‐fold increase in the number of cancer survivors noted since the 1970s, there are now
over 28 million cancer survivors worldwide. Accordingly, there is a heightened awareness …

Bell9s palsy is a common cranial neuropathy causing acute unilateral lower motor neuron
facial paralysis. Immune, infective and ischaemic mechanisms are all potential contributors to …

Neuropathy is a common complication of end‐stage kidney disease (ESKD), typically presenting
as a distal symmetrical process with greater lower‐limb than upper‐limb involvement. …

The pathophysiology of oxaliplatin‐induced neurotoxicity remains unclear, although in vitro
studies suggest involvement of voltage‐gated Na + channels. In the present study, clinical …

Administration of oxaliplatin, a platinum-based chemotherapy used extensively in the
treatment of colorectal cancer, is complicated by prominent dose-limiting neurotoxicity. Acute …

Patients with chronic kidney disease (CKD) are frequently afflicted with neurological
complications. These complications can potentially affect both the central and peripheral nervous …

Learning Objectives After completing this course, the reader will be able to: Define the
symptoms of sensory neurotoxicity in oxaliplatin‐treated patients and identify the long‐term …

CEP290-associated Leber congenital amaurosis type 10 (LCA10) is a retinal disease resulting
in childhood blindness. Sepofarsen is an RNA antisense oligonucleotide targeting the c.…

Chronic kidney disease (CKD) is a critical and rapidly growing global health problem.
Neurological complications occur in almost all patients with severe CKD, potentially affecting all …

Purpose Neurotoxicity is becoming increasingly recognized as the major dose-limiting toxicity
of oxaliplatin. Because the mechanism of oxaliplatin-induced neurotoxicity remains unclear…