Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs
used daily in oncology include clinical TNM stage, objective response and left ventricular …

Aggressive cancer phenotypes are a manifestation of many different genetic alterations that
promote rapid proliferation and metastasis. In this study, we show that stable overexpression …

Cancer cells invade by secreting degradative enzymes, which are sequestered in lysosomal
vesicles. In this study, the impact of an acidic extracellular environment on lysosome size, …

An interleaved gradient‐echo (GE) / spin‐echo (SE) EPI sequence was used to acquire images
during the first pass of a susceptibility contrast agent, in patients with brain tumors. Maps …

BACKGROUND AND PURPOSE: No widespread clinical method provides specific information
about the angiogenic characteristics of gliomas. We characterized blood volume and …

Recently, we demonstrated that vessel geometry is a significant determinant of susceptibility-induced
contrast in MRI. This is especially relevant for susceptibility-contrast enhanced MRI …

In an effort to develop MRI methods for the evaluation of tumor angiogenesis (new blood
vessel formation), MRI‐derived cerebral blood volume (CBV) information has been compared …

Functional magnetic resonance imaging (fMRI) serves as a critical tool for presurgical mapping
of eloquent cortex and changes in neurological function in patients diagnosed with brain …

Induction of tumor angiogenesis is among the hallmarks of cancer and a driver of metastatic
cascade initiation. Recent advances in high-resolution imaging enable highly detailed three-…

Neurovascular coupling, cerebrovascular remodeling and hemodynamic changes are critical
to brain function, and dysregulated in neuropathologies such as brain tumors. Interrogating …