Cavernous vascular malformations occur with a frequency of 1:200 and can cause recurrent
headaches, seizures and hemorrhagic stroke if located in the brain. Familial cerebral …

Matrix metalloproteinases (MMPs) are implicated in the pathogenesis of inflammatory disorders
of the central nervous system (CNS) whereas the contribution of the major endogenous …

Motility of unicellular organisms occurred early in evolution with the emergence of cilia and
flagella. In vertebrates, motile cilia are required for numerous functions such as clearance of …

Background The mechanisms by which any upper respiratory virus, including SARS-CoV-2,
impairs chemosensory function are not known. COVID-19 is frequently associated with …

IL-17–producing CD8 + T (Tc17) cells are detectible in multiple sclerosis (MS) lesions;
however, their contribution to the disease is unknown. To identify functions of Tc17 cells, we …

Patients with primary brain tumors have bleak prognoses and there is an urgent desire to
identify new markers for sensitive diagnosis and new therapeutic targets for effective treatment. …

The role of IL-12 in the evolution of immunoinflammatory responses at a localized tissue
level was investigated. Transgenic mice were developed with expression of either both the IL-…

The matrix metalloproteinases (MMPs) are a family of zinc‐dependent extracellular
proteases that have been implicated in CNS development and disease. Crucial homeostatic …

Background and purpose: Gliosarcomas are rare biphasic neoplasms of the central nervous
system composed of a glioblastoma multiforme (GBM) admixed with a sarcomatous …

An imbalance between matrix metalloproteinases (MMPs) and inhibitors of MMPs (TIMPs)
may contribute to tissue destruction that is found in various inflammatory disorders. To …