The First Key Symposium was held in Stockholm, Sweden, 2–5 September 2003. The aim
of the symposium was to integrate clinical and epidemiological perspectives on the topic of …

Background and Purpose— This scientific statement provides an overview of the evidence
on vascular contributions to cognitive impairment and dementia. Vascular contributions to …

Mild cognitive impairment (MCI) is a recently described syndrome that is currently thought of
as a transition phase between healthy cognitive ageing and dementia. Although this notion …

Numerous anatomical and brain imaging studies find substantial differences in brain
structure between men and women across the span of human aging. The ability to extend the …

Criteria for the diagnosis of vascular dementia (VaD) that are reliable, valid, and readily
applicable in a variety of settings are urgently needed for both clinical and research purposes. …

Objective To assess the association of MRI white matter hyperintensities (WMHI) with cognitive
performance, cerebral structure, and cerebral metabolism in 51 healthy individuals aged …

Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features
seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter …

Background Individuals diagnosed as having mild cognitive impairment (MCI) have a high
likelihood of progressing to dementia within 3 to 5 years, but not all individuals with MCI …

The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …

Background and Purpose— MRI segmentation and mapping techniques were used to
assess evidence in support of categorical distinctions between periventricular white matter …