While an extensive literature examines the diversification‐performance relationship, little
agreement exists concerning the nature of this relationship. Both theoretical and empirical …

Medicine has traditionally focused on relieving patient symptoms. However, in developed
countries, maintaining good health increasingly involves management of such problems as …

Objective. Human papillomavirus (HPV) infection is a significant risk factor for uterine cervical
carcinoma. However, the role of HPV infection in oral squamous cell carcinoma (OSCC) is …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is familial in 10%
of cases. We have identified a missense mutation in the gene encoding fused in sarcoma (…

Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we
report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, …

… c, Western blotting for Ikaros using a C-terminus-specific polyclonal antibody. Ik6 was
only detectable in cases with IKZF1 Δ3–6. The Δ1–6 and Δ2–6 deletions do not produce a …

Chromosomal aberrations are a hallmark of acute lymphoblastic leukaemia (ALL) but alone
fail to induce leukaemia. To identify cooperating oncogenic lesions, we performed a genome…

We describe the landscape of somatic genomic alterations based on multidimensional and
comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify …

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder characterized pathologically
by ubiquitinated TAR DNA binding protein (TDP-43) inclusions. The function of TDP-43 …

A major cause of aging is thought to result from the cumulative effects of cell loss over time.
In yeast, caloric restriction (CR) delays aging by activating the Sir2 deacetylase. Here we …