Neurotoxicity is a recognized complication of cyclosporin A (CsA) therapy in patients undergoing
organ transplantation. It is most commonly manifested by fever, seizures, and altered …

Background. Older medical patients often experience a decline in function associated with
hospitalization. Some of this decline is already established at hospital admission, whereas …

Some recent epidemiologic studies have reported a nonlinear dose‐response in the
relationship between coffee consumption and health risks, such that the risks increase …

We have recently demonstrated dose-dependency of caffeine metabolism under multiple
dosing conditions. Whether there are persistent pharmacodynamic actions of caffeine under …

… relative to rise and fall of Cp. Second, a "tolerance" compartment also links Cp to E, but to
the … the rate of onset and decline of tolerance after exposure to Cp, (k101) and the steady-state …

The Brisbane Cardiac Consortium Clinical Support Systems Program used multiple strategies
in optimising quality of care of patients with either of two cardiac conditions. One of these …

Since most of the toxicity associated with class 1B antiarrhythmic drugs is dose-related, this
review examines adverse effects seen in both therapeutic practice and accidental or …

Background Clinical practice guidelines have been developed to improve screening,
prevention and management of delirium. Aims To implement delirium guidelines in general …

A stable isotope‐labeled drug method was used to determine the absolute bioavailability
and absorption kinetics of a transdermal nicotine‐delivery system (TTS). TTSs are being …

Objectives : This study sought to measure the impact on all-cause death or readmission of
adding center-based exercise training (ET) to disease management programs for patients with …