Objectives: To present a comprehensive review of the existing neuropsychological and
neuroimaging literature on bipolar affective disorder. This review critically evaluates two common …

BACKGROUND: The neurobiological underpinnings of bipolar disorder are not well
understood. Previous neuroimaging findings have been inconsistent; however, new methods for …

The 22q11.2 deletion syndrome (velocardiofacial/DiGeorge syndrome) is associated with a
high frequency of learning disabilities. Although previous work has demonstrated that verbal …

Although there is considerable evidence that patients with schizophrenia fail to activate the
dorsolateral prefrontal cortex (DLPFC) to the degree seen in normal comparison subjects …

Objective Chromosome 22q11.2 deletion syndrome is a neurogenetic disorder associated
with high rates of schizophrenia and other psychiatric conditions. The authors report what is to …

Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well
understood. Structural brain differences have been associated with BD, but results from …

It is increasingly accepted that the imprecision of categorical psychiatric diagnoses can be a
limiting factor in understanding the genetic basis of human behavioral abnormalities. …

Introduction: Research on prediction and prevention of schizophrenia has increasingly focused
on prodromal (prepsychosis) social and role dysfunction as developmentally early, stable…

Social cognitive impairments are consistently reported in schizophrenia and are associated
with functional outcome. We currently know very little about whether these impairments are …

Background Individuals at clinical high risk (CHR) who progress to fully psychotic symptoms
have been observed to show a steeper rate of cortical gray matter reduction compared with …