Dysfunction of the central nervous system (CNS) is a prominent feature of the acquired
immune deficiency syndrome (AIDS). Many of these patients have a subacute encephalitis …

To determine the neuropathological substrate of human immunodeficiency virus (HIV)‐associated
neurocognitive disorders, we examined persons with acquired immunodeficiency …

Microglia constitute the primary resident immune surveillance cell in the brain and are thought
to play a significant role in the pathogenesis of several neurodegenerative disorders, such …

A spectrum of neurocognitive defects, termed human immunodeficiency virus type 1 (HIV‐1)–associated
cognitive/motor complex, has been described in patients with acquired …

Clinical and pathologicals evidence of subcortical central nervous system (CNS) damage is
observed commonly in patients with human immunodeficiency virus (HIV) encephalitis. …

The role of extracellular matrix (ECM) in neurological development, function and degeneration
has evolved from a simplistic physical adhesion to a system of intricate cellular signaling. …

Immune activation leads to accumulations of the neurotoxin and kynurenine pathway
metabolite quinolinic acid within the central nervous system of human patients. Whereas …

Approximately one quarter of patients with AIDS develop severe cognitive deficits called HIV‐associated
dementia complex (ADC). There is some controversy regarding the importance …

HIV-associated disease of the nervous system: Review of nomenclature and proposal for
neuropathology-based terminology — Mayo Clinic Skip to main navigation Skip to search Skip …

Background CHI3L1 (YKL-40) is up-regulated in a variety of inflammatory conditions and
cancers. We have previously reported elevated CHI3L1 concentration in the cerebrospinal fluid …