The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in research
and clinical practice. Scientific advances in the past 7 years suggest that they might no …

Background Natalizumab is the first α 4 integrin antagonist in a new class of selective
adhesion-molecule inhibitors. We report the results of a two-year phase 3 trial of natalizumab in …

We compared MRI criteria used to predict conversion of suspected multiple sclerosis to
clinically definite multiple sclerosis. Seventy-four patients with clinically isolated neurological …

Background In patients with multiple sclerosis, inflammatory brain lesions appear to arise from
autoimmune responses involving activated lymphocytes and monocytes. The glycoprotein …

Background BG-12 (dimethyl fumarate) is in development as an oral treatment for relapsing–remitting
multiple sclerosis, which is commonly treated with parenteral agents (interferon or …

Clinically isolated syndromes (CIS), such as optic neuritis, brainstem or spinal cord syndromes
are frequently the first clinical presentations of multiple sclerosis. However, not all CIS …

We have measured the inclusive b→ s γ branching ratio to be (2.32±0.57±0.35)× 10− 4,
where the first error is statistical and the second is systematic. Upper and lower limits on the …

Background In patients with isolated syndromes that are clinically suggestive of multiple
sclerosis, such as optic neuritis or brain-stem or spinal cord syndromes, the presence of lesions …

The new detector for data recording by the CLEO collaboration at the Cornell Electron
Storage Ring is described. This detector has been designed to optimize studying e + e − …

This study identifies by microautoradiography activated microglia/macrophages as the main
cell type expressing the peripheral benzodiazepine binding site (PBBS) at sites of active …