The delivery of many potentially therapeutic and diagnostic compounds to specific areas of
the brain is restricted by brain barriers, of which the most well known are the blood–brain …

OBJECTIVE: This article reviews historical aspects of the blood-brain barrier (BBB) and recent
advances in mechanisms to deliver therapeutic agents across the BBB for the treatment of …

… A T2*-weighted MRI image shows decreased signal along penetrating arterioles in the
cortex 2 h after an intrathecal cisternal injection of an iron oxide contrast agent (EA Neuwelt, …

Standardized guidelines for the baseline evaluation and response assessment of primary
CNS lymphoma (PCNSL) are critical to ensure comparability among clinical trials for newly …

PURPOSE To examine behavioral dimensions of treatment outcomes for patients receiving
cranial irradiation. Radiation encephalopathy is one of these and refers to significant …

Gadolinium (Gd) based contrast agents (GBCAs) in magnetic resonance imaging (MRI) are
used in daily clinical practice and appear safe in most patients; however, nephrogenic …

The brain is in many ways an immunologically and pharmacologically privileged site. The
blood–brain barrier (BBB) of the cerebrovascular endothelium and its participation in the …

Superparamagnetic iron oxide nanoparticles have diverse diagnostic and potential
therapeutic applications in the central nervous system (CNS). They are useful as magnetic …

BACKGROUND The aim of this study was to determine the safety and efficacy of intraarterial
chemotherapy with osmotic opening of the blood‐brain barrier (BBB) for the treatment of …

… In a PNET brain tumor animal model using two high-dose otoprotective thiol drugs,
Neuwelt et al34 showed that the efficacy of chemotherapy was not influenced if the timing of …