High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar …

…, K Nakata, BC Trapnell, T Terakawa, E Hamano… - Blood, 2004 - ashpublications.org
… Micro-ELISA plates (Nunc, Roskilde, Denmark) were coated with rhGM-CSF produced in
E coli (… described above and was expressed as an OD ratio to that of E coli-derived rhGM-CSF. …

Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population

E Hamano, M Hijikata, S Itoyama, T Quy, NC Phi… - Biochemical and …, 2005 - Elsevier
We hypothesized that host antiviral genes induced by type I interferons might affect the
natural course of severe acute respiratory syndrome (SARS). We analyzed single nucleotide …

Granulocyte-macrophage colony–stimulating factor and lung immunity in pulmonary alveolar proteinosis

R Tazawa, E Hamano, T Arai, H Ohta… - American journal of …, 2005 - atsjournals.org
The anti–granulocyte-macrophage colony–stimulating factor (GM-CSF) autoantibody is inferred
to cause idiopathic pulmonary alveolar proteinosis (iPAP): the antibody neutralizes GM-…

Clinical features of secondary pulmonary alveolar proteinosis: pre-mortem cases in Japan

…, T Saraya, Y Inoue, E Hamano… - European …, 2011 - Eur Respiratory Soc
REFERENCES 1 Zhernakova A, van Diemen CC, Wijmenga C. Detecting shared pathogenesis
from the shared genetics of immune-related diseases. Nat Rev Genet 2009; 10: 43–55. 2 …

Relationship of anti-GM-CSF antibody concentration, surfactant protein A and B levels, and serum LDH to pulmonary parameters and response to GM-CSF therapy in …

…, K Nakata, JJ Presneill, OD Schoch, E Hamano… - Thorax, 2003 - thorax.bmj.com
Background: Conventional measures of the severity of alveolar proteinosis (AP) include
alveolar-arterial oxygen gradient ([A – a]Do 2 ), vital capacity (VC), and carbon monoxide …

Genome structure‐based screening identified epigenetically silenced microRNA associated with invasiveness in non‐small‐cell lung cancer

K Watanabe, N Emoto, E Hamano… - … journal of cancer, 2012 - Wiley Online Library
… 2e). To analyze the relation of the CpG island methylation status and miRNA expression,
we … 2e), and we could not design appropriate primers in this region. PCR amplification was …

Clinical implications of the cortical hyperintensity belt sign in fluid-attenuated inversion recovery images after bypass surgery for moyamoya disease

E Hamano, H Kataoka, N Morita, D Maruyama… - Journal of …, 2017 - thejns.org
OBJECTIVE Transient neurological symptoms are frequently observed during the early
postoperative period after direct bypass surgery for moyamoya disease. Abnormal signal …

Identification of G0S2 as a gene frequently methylated in squamous lung cancer by combination of in silico and experimental approaches

…, N Emoto, N Aki, H Kage, E Hamano… - … journal of cancer, 2010 - Wiley Online Library
Epigenetic changes can lead to abnormal expression of genes in cancer, and several genes
have been reported to have aberrant promoter DNA methylation in non‐small‐cell lung …

CpG island methylation of microRNAs is associated with tumor size and recurrence of non‐small‐cell lung cancer

…, K Watanabe, N Emoto, H Kage, E Hamano… - Cancer …, 2011 - Wiley Online Library
We investigated whether the CpG island methylation of certain microRNAs was associated
with the clinicopathological features and the prognosis of non‐small‐cell lung cancer. The …

Huge Supratentorial Extraventricular Anaplastic Ependymoma Presenting With Massive Calcification—Case Report—

E Hamano, S Tsutsumi, Y Nonaka, Y Abe… - Neurologia medico …, 2010 - jstage.jst.go.jp
A 15-year-old boy presented with an anaplastic supratentorial ependymoma causing massive
intratumoral calcification, without contributory medical and family history, and manifesting …