Interferon-α (IFNα) and IFNβ, collectively known as type I IFNs, are the major effector cytokines
of the host immune response against viral infections. However, the production of type I …

Blebs are cellular protrusions that have been shown to be instrumental for cell migration in
development and disease. Bleb expansion is driven by hydrostatic pressure generated in the …

The vasa gene, essential for germ-cell development, was originally identified in Drosophila,
and has since been found in other invertebrates and vertebrates. Analysis of these vasa …

Hydroxymethylglutaryl coenzyme A reductase (HMGCoAR) is required for isoprenoid and
cholesterol biosynthesis. In Drosophila, reduced HMGCoAR activity results in germ cell …

… Dr Humbert, Dr Ishida, Dr Alam, Dr Lord, Dr Sanger, Dr Lillemoe, E. Scher, Dr Kim, Dr Raz,
and Dr Tanweer participated in data abstraction and article revision. Dr Trivedi performed the …

Piwi proteins specify an animal-specific subclass of the Argonaute family that, in vertebrates,
is specifically expressed in germ cells. We demonstrate that zebrafish Piwi (Ziwi) is …

… 1SS-DNAs suppress IgE antibody formation Immunoglobulin E production is a consequence
of extreme Th2 responses" and can lead to potentially fatal anaphylactic reactions to …

Vaccination with naked DNA elicits cellular and humoral immune responses that have a T
helper cell type 1 bias. However, plasmid vectors expressing large amounts of gene product …

… Full-length mouse MyD88 was amplified by polymerase chain reaction with reverse
transcription (RT–PCR) using cDNA from BMDMs, and fused to a triple Flag tag and subunit B of E. …

Background & Aims : We tested whether the attenuation of experimental colitis by live probiotic
bacteria is due to their immunostimulatory DNA, whether toll-like receptor (TLR) signaling …