Pericytes are uniquely positioned within the neurovascular unit to serve as vital integrators,
coordinators and effectors of many neurovascular functions, including angiogenesis, blood-…

… and luminal sides of the BBB in vivo, respectively (EA Winkler, Y. Sallstrom, D. Zhu, R. …
LRP1 is also expressed at the luminal side of the BBB (EA Winkler, Y. Sallstrom, D. Zhu, R. …

Traumatic brain injury (TBI) is a complex and heterogeneous disorder with a tremendous
public health burden. It is grossly defined as an alteration in brain function or other evidence of …

Cerebrovascular diseases are a leading cause of death and neurologic disability. Further
understanding of disease mechanisms and therapeutic strategies requires a deeper …

Human apolipoprotein E has three isoforms: APOE2, APOE3 and APOE4 1 . APOE4 is a
major genetic risk factor for Alzheimer’s disease 2 , 3 and is associated with Down’s syndrome …

Pericytes play a key role in the development of cerebral microcirculation. The exact role of
pericytes in the neurovascular unit in the adult brain and during brain aging remains, however…

The glucose transporter GLUT1 at the blood-brain barrier (BBB) mediates glucose transport
into the brain. Alzheimer's disease is characterized by early reductions in glucose transport …

The blood–brain barrier and blood–spinal cord barrier (BSCB) limit the entry of plasma
components and erythrocytes into the central nervous system (CNS). Pericytes play a key role in …

Humans with ALS and transgenic rodents expressing ALS-associated superoxide dismutase
(SOD1) mutations develop spontaneous blood–spinal cord barrier (BSCB) breakdown, …

Pericytes are cells in the blood–brain barrier that degenerate in Alzheimer’s disease (AD), a
neurological disorder associated with neurovascular dysfunction, abnormal elevation of …