The current landscape of immunotherapy for pediatric brain tumors
EI Hwang, EJ Sayour, CT Flores, G Grant… - Nature Cancer, 2022 - nature.com
Pediatric central nervous system tumors are the most common solid malignancies in childhood,
and aggressive therapy often leads to long-term sequelae in survivors, making these …
and aggressive therapy often leads to long-term sequelae in survivors, making these …
Heterologous production of flavanones in Escherichia coli: potential for combinatorial biosynthesis of flavonoids in bacteria
M Kaneko, EI Hwang, Y Ohnishi… - Journal of Industrial …, 2003 - Springer
Chalcones, the central precursor of flavonoids, are synthesized exclusively in plants from
tyrosine and phenylalanine via the sequential reaction of phenylalanine ammonia-lyase (PAL), …
tyrosine and phenylalanine via the sequential reaction of phenylalanine ammonia-lyase (PAL), …
Production of Plant-Specific Flavanones by Escherichia coli Containing an Artificial Gene Cluster
EI Hwang, M Kaneko, Y Ohnishi… - Applied and …, 2003 - Am Soc Microbiol
… EI Hwang was supported by the Japan Society for the Promotion of Science. This work
was supported by a research grant from the Noda Institute for Scientific Research, by the Bio …
was supported by a research grant from the Noda Institute for Scientific Research, by the Bio …
Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma
Diffuse Intrinsic Pontine Gliomas (DIPGs) are deadly paediatric brain tumours where needle
biopsies help guide diagnosis and targeted therapies. To address spatial heterogeneity, …
biopsies help guide diagnosis and targeted therapies. To address spatial heterogeneity, …
[PDF][PDF] Integrated (epi)-genomic analyses identify subgroup-specific therapeutic targets in CNS rhabdoid tumors
…, B Wilson, J Hukin, AS Carret, TE Van Meter, EI Hwang… - Cancer cell, 2016 - cell.com
We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two
transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying …
transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying …
[HTML][HTML] The role of NG2 proteoglycan in glioma
S Yadavilli, EI Hwang, RJ Packer, J Nazarian - Translational Oncology, 2016 - Elsevier
Neuron glia antigen-2 ((NG2), also known as chondroitin sulphate proteoglycan 4, or
melanoma-associated chondroitin sulfate proteoglycan) is a type-1 membrane protein expressed …
melanoma-associated chondroitin sulfate proteoglycan) is a type-1 membrane protein expressed …
Clinically relevant and minimally invasive tumor surveillance of pediatric diffuse midline gliomas using patient-derived liquid biopsy
…, SN Magge, N Gupta, JS Myseros, EI Hwang… - Clinical Cancer …, 2018 - AACR
Purpose: Pediatric diffuse midline glioma (DMG) are highly malignant tumors with poor
clinical outcomes. Over 70% of patients with DMG harbor the histone 3 p.K27M (H3K27M) …
clinical outcomes. Over 70% of patients with DMG harbor the histone 3 p.K27M (H3K27M) …
Long‐term efficacy and toxicity of bevacizumab‐based therapy in children with recurrent low‐grade gliomas
Background Because definitive resection or radiotherapy for pediatric low‐grade gliomas (LGGs)
may be associated with severe and permanent adverse effects, medical management …
may be associated with severe and permanent adverse effects, medical management …
Marked recovery of vision in children with optic pathway gliomas treated with bevacizumab
RA Avery, EI Hwang, RI Jakacki… - JAMA …, 2014 - jamanetwork.com
Importance Children with optic pathway gliomas (OPGs) frequently experience vision loss
from their tumors. Standard front-line treatment using carboplatin-based chemotherapy …
from their tumors. Standard front-line treatment using carboplatin-based chemotherapy …
Heterogeneity within the PF-EPN-B ependymoma subgroup
Posterior fossa ependymoma comprise three distinct molecular variants, termed PF-EPN-A (PFA),
PF-EPN-B (PFB), and PF-EPN-SE (subependymoma). Clinically, they are very …
PF-EPN-B (PFB), and PF-EPN-SE (subependymoma). Clinically, they are very …
