A modern understanding of how cerebral cortical lesions develop after acute brain injury is
based on Aristides Leão’s historic discoveries of spreading depression and asphyxial/anoxic …

Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal
transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable …

Hepatitis C virus is a serious infection causing cirrhosis, liver cancer, and death. The recent
development of direct-acting antivirals has dramatically improved tolerability of treatment and …

American Clinical Neurophysiology Society's Standardized Cri... : Journal of Clinical
Neurophysiology American Clinical Neurophysiology Society's Standardized Critical Care EEG …

Background: Rapid and easy clinical assessments for volumes of infarction and perfusion
mismatch are needed. We tested whether simple geometric models generated accurate …

… Rosenthal and Ona Wu authors contributed equally to this work. … Rosenthal, Ona Wu, Early
detection of consciousness in patients with acute severe traumatic brain injury, Brain, Volume …

Background Infective endocarditis is a serious infection, often resulting from injection drug
use. Inpatient treatment regularly focuses on management of infection without attention to the …

Background Benzodiazepine-refractory, or established, status epilepticus is thought to be of
similar pathophysiology in children and adults, but differences in underlying aetiology and …

Objectives: Telemedicine‐enabled acute stroke consultation (TeleStroke) may be useful to
determine eligibility for treatment with tissue plasminogen activator (tPA) and provide support …

Background People who inject drugs have a high prevalence of hepatitis C virus (HCV) and
significant disease associated with drug use; however, HCV treatment often occurs in …