Introduction During the past three decades, improvements in the treatment of childhood
leukemia have resulted in high cure rates, particularly for acute lymphoblastic leukemia (ALL). …

Background Little information is available about the diagnosis and management of acute
methotrexate (MTX)-induced encephalopathy. Methods We reviewed clinical and magnetic …

PURPOSE The Children’s Oncology Group trial ACNS0121 estimated event-free survival (EFS)
and overall survival for children with intracranial ependymoma treated with surgery, …

Posterior fossa syndrome is characterized by cerebellar dysfunction, oromotor/oculomotor
apraxia, emotional lability and mutism in patients after infratentorial injury. The underlying …

Purpose To identify predisposing factors, radiologic features, and clinical outcome of posterior
reversible leucoencephalopathy (PRES) in children receiving cancer treatment. Methods …

Purpose White matter lesions (WMLs) have been described as a delayed effect of cranial
irradiation in children with brain tumors, or a transient subacute effect characterized by an …

BACKGROUND: To extend investigation beyond global cognitive measures prevalent in the
literature, this study examined attention and working memory (WM) abilities of survivors of …

Introduction Medical advances over the last several decades, including CNS prophylaxis,
have greatly increased survival in children with leukemia. As survival rates have increased, …

Systemic and intrathecal methotrexate (MTX) are integral components of acute lymphoblastic
leukemia (ALL) therapy, but can be associated with neurotoxicity. We describe here the …

BACKGROUND. High‐dose chemotherapy (HDCT) with autologous stem cell rescue (ASCR)
has been reported to be effective in treating children with recurrent central nervous system (…