Cognitive dysfunction is core to schizophrenia, and remains poorly treated by existing
therapies. A prominent hypothesis suggests that many symptoms arise from N-methyl-d-aspartate …

Dynamic gain and loss of synapses is fundamental to healthy brain function. While Alzheimer’s
Disease (AD) treatment strategies have largely focussed on beta-amyloid and tau protein …

Functional neurological disorder (FND) is a common cause of persistent and disabling
neurological symptoms. These symptoms are varied and include abnormal control of movement, …

Worked and unworked astragalus bones from a variety of different animals have been excavated
throughout the eastern Mediterranean and Near East in several different contexts. This …

Background— Lung hypoplasia and persistent pulmonary hypertension of the newborn limit
survival in congenital diaphragmatic hernia (CDH). Unlike other diseases resulting in …

Cholinergic neurotransmission throughout the neocortex and hippocampus regulates arousal,
learning, and attention. However, owing to the poorly characterized timing and location of …

We previously reported involvement of right prefrontal cholinergic activity in veridical signal
detection. Here, we first recorded real-time acetylcholine release in prefrontal cortex (PFC) …

… access) which allowed for normal growth; animals weighed 400–500 g at the time of testing.
… In the variable interval responding experiments of Gilmour et al. (2009) and the four-stage …

Objective: In recent years, the Low Vision Clinic (LVC) appeared to have a large percentage
of patients admitting to phantom vision (Charles Bonnet syndrome [CBS]). The objective of …

Based on the glutamatergic hypothesis of schizophrenia we assessed the effects of a novel
mGlu5 positive allosteric modulator, LSN2463359 [N-(1-methylethyl)-5-(pyridin-4-ylethynyl) …