Pathways to neuronal injury and apoptosis in HIV-associated dementia
Human immunodeficiency virus-1 (HIV-1) can induce dementia with alarming occurrence
worldwide. The mechanism remains poorly understood, but discovery in brain of HIV-1-binding …
worldwide. The mechanism remains poorly understood, but discovery in brain of HIV-1-binding …
Microglia biology in health and disease
GA Garden, T Möller - Journal of Neuroimmune Pharmacology, 2006 - Springer
Microglia cells are resident central nervous system (CNS) leukocytes that regulate innate
immunity and participate in adaptive immune responses in CNS tissue. However, microglia …
immunity and participate in adaptive immune responses in CNS tissue. However, microglia …
Cytokines in CAR T cell–associated neurotoxicity
Chimeric antigen receptor (CAR) T cells provide new therapeutic options for patients with
relapsed/refractory hematologic malignancies. However, neurotoxicity is a frequent, and …
relapsed/refractory hematologic malignancies. However, neurotoxicity is a frequent, and …
Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI—initial results
…, NL Polissar, C Isaac, MS Ferguson, GA Garden… - Stroke, 2006 - Am Heart Assoc
Background and Purpose— MRI is able to quantify carotid plaque size and composition with
good accuracy and reproducibility and provides an opportunity to prospectively examine …
good accuracy and reproducibility and provides an opportunity to prospectively examine …
A simple composite phenotype scoring system for evaluating mouse models of cerebellar ataxia
…, TD Baughan, AR La Spada, GA Garden - JoVE (Journal of …, 2010 - jove.com
… Garden contributed to this manuscript equally. … Guyenet, SJ, Furrer, SA, Damian, VM,
Baughan, TD, La Spada, AR, Garden, GA A Simple Composite Phenotype Scoring System for …
Baughan, TD, La Spada, AR, Garden, GA A Simple Composite Phenotype Scoring System for …
Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate
…, MR Fairgrieve, JC Gatenby, T Richards, GA Garden… - Nature medicine, 2016 - nature.com
We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a
pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved …
pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved …
Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport
SK Custer, GA Garden, N Gill, U Rueb, RT Libby… - Nature …, 2006 - nature.com
Non-neuronal cells may be pivotal in neurodegenerative disease, but the mechanistic basis
of this effect remains ill-defined. In the polyglutamine disease spinocerebellar ataxia type 7 (…
of this effect remains ill-defined. In the polyglutamine disease spinocerebellar ataxia type 7 (…
Microglia in human immunodeficiency virus‐associated neurodegeneration
GA Garden - Glia, 2002 - Wiley Online Library
Infection with the human immunodeficiency virus (HIV) is associated with a syndrome of
cognitive and motor abnormalities that may develop in the absence of opportunistic infections. …
cognitive and motor abnormalities that may develop in the absence of opportunistic infections. …
Caspase cascades in human immunodeficiency virus-associated neurodegeneration
GA Garden, SL Budd, E Tsai, L Hanson… - Journal of …, 2002 - Soc Neuroscience
Many patients infected with human immunodeficiency virus-1 (HIV-1) develop a syndrome
of neurologic deterioration known as HIV-associated dementia (HAD). Neurons are not …
of neurologic deterioration known as HIV-associated dementia (HAD). Neurons are not …
Human microglia show unique transcriptional changes in Alzheimer's disease
Microglia, the innate immune cells of the brain, influence Alzheimer’s disease (AD) progression
and are potential therapeutic targets. However, microglia exhibit diverse functions, the …
and are potential therapeutic targets. However, microglia exhibit diverse functions, the …
