User profiles for H.D. Skinner
 | Heath SkinnerUniversity of Pittsburgh, UPMC Hillman Cancer Center Verified email at upmc.edu Cited by 7030 |
TP53 Disruptive Mutations Lead to Head and Neck Cancer Treatment Failure through Inhibition of Radiation-Induced Senescence
HD Skinner, VC Sandulache, TJ Ow, RE Meyn… - Clinical cancer …, 2012 - AACR
Purpose: Mortality of patients with head and neck squamous cell carcinoma (HNSCC) is
primarily driven by tumor cell radioresistance leading to locoregional recurrence (LRR). In this …
primarily driven by tumor cell radioresistance leading to locoregional recurrence (LRR). In this …
[HTML][HTML] Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1α, HDM2, and p70S6K1 in response to …
HD Skinner, JZ Zheng, J Fang, F Agani… - Journal of Biological …, 2004 - ASBMB
Vascular endothelial growth factor (VEGF) expression is elevated in ovarian and other cancer
cells. However, the mechanism that causes the increase in VEGF expression still remains …
cells. However, the mechanism that causes the increase in VEGF expression still remains …
[HTML][HTML] Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation
…, AM Ward, VC Sandulache, SA Jasser, HD Skinner… - Molecular cell, 2014 - cell.com
Many mutant p53 proteins (mutp53s) exert oncogenic gain-of-function (GOF) properties, but
the mechanisms mediating these functions remain poorly defined. We show here that GOF …
the mechanisms mediating these functions remain poorly defined. We show here that GOF …
Association of body composition with survival and locoregional control of radiotherapy-treated head and neck squamous cell carcinoma
…, S Frank, J Phan, B Beadle, HD Skinner… - JAMA …, 2016 - jamanetwork.com
Importance Major weight loss is common in patients with head and neck squamous cell
carcinoma (HNSCC) who undergo radiotherapy (RT). How baseline and posttreatment body …
carcinoma (HNSCC) who undergo radiotherapy (RT). How baseline and posttreatment body …
Intraoperative margin assessment in head and neck cancer: a case of misuse and abuse?
…, MA Varvares, DP Zandberg, HD Skinner… - Head and neck …, 2020 - Springer
Surgical removal with negative margins is the preferred management of oral squamous cell
carcinomas. This review summarizes statements by professional organizations and data …
carcinomas. This review summarizes statements by professional organizations and data …
[HTML][HTML] Salvage pembrolizumab added to kinase inhibitor therapy for the treatment of anaplastic thyroid carcinoma
…, MD Williams, GB Gunn, H Grosu, HD Skinner… - … for immunotherapy of …, 2018 - Springer
Background Anaplastic thyroid carcinoma (ATC) is a rare but deadly form of thyroid cancer.
Kinase inhibitors kinase inhibitors have shown clinical efficacy in the management of ATC, …
Kinase inhibitors kinase inhibitors have shown clinical efficacy in the management of ATC, …
Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer
…, CR Pickering, A Ward, A Patel, JS Yordy, HD Skinner… - Cancer research, 2015 - AACR
TP53 is the most frequently altered gene in head and neck squamous cell carcinoma, with
mutations occurring in over two-thirds of cases, but the prognostic significance of these …
mutations occurring in over two-thirds of cases, but the prognostic significance of these …
Charged-particle therapy for hepatocellular carcinoma
Historically, the use of external-beam radiotherapy for hepatocellular carcinoma (HCC) has
been limited by toxicity to the uninvolved liver and surrounding structures. Advances in …
been limited by toxicity to the uninvolved liver and surrounding structures. Advances in …
A novel YAP1 inhibitor targets CSC-enriched radiation-resistant cells and exerts strong antitumor activity in esophageal adenocarcinoma
…, AW Scott, J Jin, L Ma, X Dong, HD Skinner… - Molecular cancer …, 2018 - AACR
… In collaboration with HD Skinner (MD Anderson Cancer Center), we developed radiation-resistant
Flo-1 XTR cells as indicated in Fig. 4. We observed that these radiation-resistant XTR …
Flo-1 XTR cells as indicated in Fig. 4. We observed that these radiation-resistant XTR …
Pathological complete response in patients with esophageal cancer after the trimodality approach: The association with baseline variables and survival—The …
…, F G. Amlashi, Z Liao, R Komaki, SH Lin, HD Skinner… - Cancer, 2017 - Wiley Online Library
BACKGROUND Reports are limited regarding clinical and pretreatment features that might
predict a pathological complete response (pathCR) after treatment in patients with …
predict a pathological complete response (pathCR) after treatment in patients with …
