Generic acquisition protocol for quantitative MRI of the spinal cord
…, S Mackey, E Martinez-Heras, L Mattera, I Nestrasil… - Nature protocols, 2021 - nature.com
Quantitative spinal cord (SC) magnetic resonance imaging (MRI) presents many challenges,
including a lack of standardized imaging protocols. Here we present a prospectively …
including a lack of standardized imaging protocols. Here we present a prospectively …
T1ρ and T2ρ MRI in the evaluation of Parkinson's disease
I Nestrasil, S Michaeli, T Liimatainen, CE Rydeen… - Journal of …, 2010 - Springer
Prior work has shown that adiabatic T 1ρ and T 2ρ relaxation time constants may have sensitivity
to cellular changes and the presence of iron, respectively, in Parkinson’s disease (PD). …
to cellular changes and the presence of iron, respectively, in Parkinson’s disease (PD). …
[HTML][HTML] Distinct progression patterns of brain disease in infantile and juvenile gangliosidoses: Volumetric quantitative MRI study
I Nestrasil, A Ahmed, JM Utz, K Rudser… - Molecular genetics and …, 2018 - Elsevier
Background GM1-gangliosidosis and GM2-gangliosidosis (Tay-Sachs disease and Sandhoff
disease) are unrelenting heritable neurodegenerative conditions of lysosomal ganglioside …
disease) are unrelenting heritable neurodegenerative conditions of lysosomal ganglioside …
[HTML][HTML] Tractography dissection variability: What happens when 42 groups dissect 14 white matter bundles on the same dataset?
…, E Brignoni-Perez, C Lebel, JE Reynolds, I Nestrasil… - Neuroimage, 2021 - Elsevier
White matter bundle segmentation using diffusion MRI fiber tractography has become the
method of choice to identify white matter fiber pathways in vivo in human brains. However, like …
method of choice to identify white matter fiber pathways in vivo in human brains. However, like …
[HTML][HTML] Quantitative neuroimaging in mucopolysaccharidoses clinical trials
I Nestrasil, L Vedolin - Molecular genetics and metabolism, 2017 - Elsevier
The mucopolysaccharidosis (MPS) disorders are rare lysosomal storage disorders caused
by mutations in lysosomal enzymes involved in glycosaminoglycan (GAG) degradation. The …
by mutations in lysosomal enzymes involved in glycosaminoglycan (GAG) degradation. The …
[HTML][HTML] Neurocognitive and somatic stabilization in pediatric patients with severe Mucopolysaccharidosis Type I after 52 weeks of intravenous brain-penetrating …
…, AD Corte, M Schmidt, RJ Boado, I Nestrasil… - Orphanet journal of rare …, 2018 - Springer
Background Mucopolysaccharidosis (MPS) Type I (MPSI) is caused by mutations in the
gene encoding the lysosomal enzyme, α-L-iduronidase (IDUA), and a majority of patients …
gene encoding the lysosomal enzyme, α-L-iduronidase (IDUA), and a majority of patients …
[HTML][HTML] A prospective natural history study of mucopolysaccharidosis type IIIA
EG Shapiro, I Nestrasil, KA Delaney, K Rudser… - The Journal of …, 2016 - Elsevier
Objectives To characterize the clinical course of mucopolysaccharidosis type IIIA (MPS IIIA),
and identify potential endpoints for future treatment trials. Study design Children with a …
and identify potential endpoints for future treatment trials. Study design Children with a …
[HTML][HTML] Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers
…, S Mackey, E Martinez-Heras, L Mattera, I Nestrasil… - Scientific Data, 2021 - nature.com
In a companion paper by Cohen-Adad et al. we introduce the spine generic quantitative
MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and …
MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and …
Neurocognition across the spectrum of mucopolysaccharidosis type I: age, severity, and treatment
EG Shapiro, I Nestrasil, K Rudser, K Delaney… - Molecular genetics and …, 2015 - Elsevier
Objectives Precise characterization of cognitive outcomes and factors that contribute to cognitive
variability will enable better understanding of disease progression and treatment effects …
variability will enable better understanding of disease progression and treatment effects …
Unique white matter microstructural patterns in ADHD presentations—a diffusion tensor imaging study
A Svatkova, I Nestrasil, K Rudser… - Human brain …, 2016 - Wiley Online Library
Attention‐deficit/hyperactivity disorder predominantly inattentive (ADHD‐PI) and combined (ADHD‐C)
presentations are likely distinct disorders that differ neuroanatomically, …
presentations are likely distinct disorders that differ neuroanatomically, …
