… By 15 months, 25% of the Ini1+/JCyclin D1+/+ or Cyclin D1+/J mice developed tumors,
whereas none of the Ini1+/J Cyclin D1J/J mice developed tumors. Tsikitis, et al., propose that …

Atypical teratoid/rhabdoid tumor (AT/RT) is the most common malignant CNS tumor of
children below 6 months of age. The majority of AT/RTs demonstrate genomic alterations in …

… Biegel, Ph.D. received her BS degree in Biology from Union … Biegel's research is focused
on the genetics of pediatric … Biegel's research is focused on the genetics of pediatric rhabdoid …

Major international projects are underway that are aimed at creating a comprehensive catalogue
of all the genes responsible for the initiation and progression of cancer 1 , 2 , 3 , 4 , 5 , 6 …

Embryonal tumours of the central nervous system (CNS) represent a heterogeneous group
of tumours about which little is known biologically, and whose diagnosis, on the basis of …

We examined 18 atypical teratoid and rhabdoid tumors of the brain and 7 renal and 4 extrarenal
rhabdoid tumors for mutations in the candidate rhabdoid tumor suppressor gene, INI1. …

✓ Clinical and pathological features of 52 infants and children with atypical teratoid/rhabdoid
tumor (ATT/RhT) of the central nervous system are defined. This tumor is typically …

Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the
genetic alterations in this tumor type, we searched for copy number alterations using high-…

The epidermal growth factor receptor has received much interest as a target for various
antineoplastic agents, but a complication is that many normal tissues also express this receptor. …

Although the t(2;13)(q35;q14) translocation has been found in most cases of the pediatric
cancer alveolar rhabdomyosarcoma, several cases have been reported with a variant t(1;13)(…