The traditional view of the adult brain as a static organ has changed in the past three
decades, with the emergence of evidence that it remains plastic and has some regenerative …

Microglia are the first line of immune defense against central nervous system (CNS) injuries
and disorders. These highly plastic cells play dualistic roles in neuronal injury and recovery …

Previous research on stroke and traumatic brain injury (TBI) heavily emphasized pathological
alterations in neuronal cells within gray matter. However, recent studies have highlighted …

Most of the successes in experimental models of stroke have not translated well to the clinic.
One potential reason for this failure is that stroke mainly afflicts the elderly and the majority …

The radical, anionic, and group-transfer polymerization of (RS)-and (R)-a-methylene-7-methyl-7-butyrolactone
gave amorphous polymer with Tg’s ranging from 211 to 220 C. Polymer …

Objective To determine whether chronic motor deficits secondary to traumatic brain injury (TBI)
can be improved by implantation of allogeneic modified bone marrow–derived …

Oxidative stress is known to play a critical role in the pathogenesis of various disorders,
especially in ischemia/reperfusion (I/R) injury. We identified an apoptosis-inducing humoral …

Purpose: The 2021 World Health Organization (WHO) classification of central nervous
system (CNS) tumors uses an integrated approach involving histopathology and molecular …

Post-stroke treatment with omega-3 polyunsaturated fatty acids (n-3 PUFAs) may be a promising
therapy in young animals but this has not been tested in aged subjects, a population at …

A set of clinically relevant CNSL xenografts identifies a hyperactive RelA/p65-hexokinase 2
signaling axis as a driver of progression and potential therapeutic target for treatment and …