Background Alteplase is effective for treatment of acute ischaemic stroke but debate continues
about its use after longer times since stroke onset, in older patients, and among patients …

Background Most strokes are due to blockage of an artery in the brain by a blood clot. Prompt
treatment with thrombolytic drugs can restore blood flow before major brain damage has …

Methods A hybrid approach based on established processes described by Glaser15 and by
the National Institutes of Health (http://prevention. nih. gov/cdp/about. aspx) 16 was used to …

Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features
seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter …

The term cerebral small vessel disease (SVD) describes a range of neuroimaging, pathological,
and associated clinical features. Clinical features range from none, to discrete focal …

Cerebral “microvascular” disease occurs in lacunar stroke, leukoaraiosis, vascular dementia
and Alzheimer's disease. It may arise from or contribute to insidious damage to the blood–…

Small vessel disease is a disorder of cerebral microvessels that causes white matter
hyperintensities and several other common abnormalities (eg, recent small subcortical infarcts and …

Background Recombinant tissue plasminogen activator (rt-PA, alteplase) improved functional
outcome in patients treated soon after acute ischaemic stroke in randomised trials, but …

… Joanna Wardlaw: concept, funding, supervision and coordination, acquisition and … J. Wardlaw
was partly funded by the Scottish Funding Council through the SINAPSE collaboration. Go …

Completely updated edition, written by a close-knit author team Presents a unique approach
to stroke-integrated clinical management that weaves together causation, presentation, …