Role of Wnt/β-catenin signaling in hepatocellular carcinoma, pathogenesis, and clinical significance

…, AO Kaseb, M Hassan, JD Hazle… - Journal of …, 2018 - Taylor & Francis
Hepatocellular carcinoma (HCC) is one of the most common primary hepatic malignancies
and one of the fastest-growing causes of cancer-related mortality in the United States. The …

Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance

…, B Rivera, RE Price, JD Hazle… - Proceedings of the …, 2003 - National Acad Sciences
Metal nanoshells are a class of nanoparticles with tunable optical resonances. In this article,
an application of this technology to thermal ablative therapy for cancer is described. By …

[HTML][HTML] The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis

…, HY Huang, KKC Tsai, LG Flores, Y Shao, JD Hazle… - Cell, 2012 - cell.com
Akt kinase plays a central role in cell growth, metabolism, and tumorigenesis. The TRAF6
E3 ligase orchestrates IGF-1-mediated Akt ubiquitination and activation. Here, we show that …

Elastographic characterization of HIFU-induced lesions in canine livers

…, RJ Stafford, RE Price, TA Krouskop, JD Hazle… - Ultrasound in medicine …, 1999 - Elsevier
The elastographic visualization and evaluation of high-intensity focused ultrasound (HIFU)-induced
lesions were investigated. The lesions were induced in vitro in freshly excised …

Accuracy of presurgical functional MR imaging for language mapping of brain tumors: a systematic review and meta-analysis

…, JT Yang, CT Yang, YH Tsai, CY Yang, JD Hazle… - Radiology, 2018 - pubs.rsna.org
Purpose To compare functional magnetic resonance (MR) imaging for language mapping (hereafter,
language functional MR imaging) with direct cortical stimulation (DCS) in patients …

Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: characterizing an integrated antihypoxic and localized …

…, RJ Stafford, SH Cho, JW Tunnell, JD Hazle… - Nano …, 2008 - ACS Publications
We report noninvasive modulation of in vivo tumor radiation response using gold nanoshells.
Mild-temperature hyperthermia generated by near-infrared illumination of gold nanoshell-…

MR thermometry‐based feedback control of laser interstitial thermal therapy at 980 nm

…, JA Bankson, RE Price, JD Hazle - Lasers in Surgery …, 2004 - Wiley Online Library
Background and Objectives The goal of this study was to explore the feasibility of magnetic
resonance thermal imaging (MRTI)‐based feedback control of intracerebral laser interstitial …

Translating preclinical MRI methods to clinical oncology

…, P Enriquez‐Navas, R Gillies, JD Hazle… - Journal of Magnetic …, 2019 - Wiley Online Library
The complexity of modern in vivo magnetic resonance imaging (MRI) methods in oncology
has dramatically changed in the last 10 years. The field has long since moved passed its (…

Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors

…, CA Conrad, C Malloy, AD Sherry, SY Lai, JD Hazle - Cancer research, 2015 - AACR
Hyperpolarized [1- 13 C]-pyruvate has shown tremendous promise as an agent for imaging
tumor metabolism with unprecedented sensitivity and specificity. Imaging hyperpolarized …

Targeted multifunctional gold-based nanoshells for magnetic resonance-guided laser ablation of head and neck cancer

…, W Lu, M Zhong, M Zhou, G Liang, AM Elliott, JD Hazle… - Biomaterials, 2011 - Elsevier
Image-guided thermal ablation of tumors is becoming a more widely accepted minimally
invasive alternative to surgery for patients who are not good surgical candidates, such as …