… In another study of twenty-four patients with a high-energy fracture of the tibial plateau
that was treated with external fixation, Marsh and Weigel 40 found no association between …

Fracture healing is a critically important clinical event for fracture patients and for clinicians
who take care of them. The clinical evaluation of fracture healing is based on both …

As populations benefit from increasing lifespans, neurodegenerative diseases have emerged
as a critical health concern. How can the fruit fly, Drosophila melanogaster, contribute to …

The purpose of this new classification compendium is to republish the Orthopaedic Trauma
Association's (OTA) classification. The OTA classification was originally published in a …

Proteins with expanded polyglutamine repeats cause Huntington's disease and other
neurodegenerative diseases. Transcriptional dysregulation and loss of function of transcriptional co…

Although posttraumatic osteoarthritis (OA) is a common and important entity in orthopedic
practice, no data presently exist regarding its prevalence or its relative burden of disease. A …

Huntington's disease (HD) is an inherited, progressive neurological disorder that is caused
by a CAG/polyglutamine repeat expansion and for which there is no effective therapy. Recent …

Huntington's disease (HD) is characterized by the accumulation of a pathogenic protein,
Huntingtin (Htt), that contains an abnormal polyglutamine expansion. Here, we report that a …

Several dominant, late-onset neurodegenerative diseases (eg Huntington’s disease) are
caused by expansion of polyglutamine (polyQ) repeats within specific proteins. The diverse, yet …

Twenty-one complex fractures of the tibial plateau in twenty patients were treated with closed
reduction, interfragmental screw fixation of the articular fragments, and application of a …