Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre …

…, A Panigrahy, Z Patay, B Tamrazi, JY Jones… - The lancet …, 2019 - thelancet.com
Background Paediatric low-grade glioma is the most common CNS tumour of childhood.
Although overall survival is good, disease often recurs. No single universally accepted …

Imaging changes in pediatric intracranial ependymoma patients treated with proton beam radiation therapy compared to intensity modulated radiation therapy

…, M Chintagumpala, L Ketonen, JY Jones… - International Journal of …, 2015 - Elsevier
Purpose The clinical significance of magnetic resonance imaging (MRI) changes after
radiation therapy (RT) in children with ependymoma is not well defined. We compared imaging …

A phase II trial of selumetinib in children with recurrent optic pathway and hypothalamic low-grade glioma without NF1: a Pediatric Brain Tumor Consortium study

…, G Vezina, C Bregman, Z Patay, JY Jones… - Neuro …, 2021 - academic.oup.com
Background Pediatric low-grade gliomas (pLGGs) are the most common childhood brain
tumor. Progression-free survival (PFS) is much lower than overall survival, emphasizing the …

Progression‐free survival of children with localized ependymoma treated with intensity‐modulated radiation therapy or proton‐beam radiation therapy

…, A Mahajan, E Jo, AC Paulino, AM Adesina, JY Jones… - Cancer, 2017 - Wiley Online Library
BACKGROUND The treatment for childhood intracranial ependymoma includes maximal
surgical resection followed by involved‐field radiotherapy, commonly in the form of intensity‐…

[HTML][HTML] Pediatric cerebral cavernous malformations: Genetics, pathogenesis, and management

…, VM Srinivasan, AC Mohan, JY Jones… - Surgical Neurology …, 2016 - ncbi.nlm.nih.gov
A 7‑year‑old girl presented with diplopia, ataxia, and headaches. Imaging revealed a
hemorrhagic right middle cerebellar peduncle lesion suggestive of a solitary CCM [Figure 2a]. Her …

Severe neurologic side effects in patients being treated for hemophagocytic lymphohistiocytosis

…, CE Allen, T Horton, JY Jones… - Pediatric blood & …, 2009 - Wiley Online Library
Background Hemophagocytic Lymphohistiocytosis (HLH) is characterized by uncontrolled
inflammation that is generally fatal without immune modulating chemotherapy. At Texas …

Comparison of the diagnostic accuracy of PET/MRI to PET/CT-acquired FDG brain exams for seizure focus detection: a prospective study

MJ Paldino, E Yang, JY Jones, N Mahmood, A Sher… - Pediatric …, 2017 - Springer
Background There is great interest in positron emission tomography (PET)/magnetic resonance
(MR) as a clinical tool due to its capacity to provide diverse diagnostic information in a …

Performance of computed tomography of the head to evaluate for skull fractures in infants with suspected non-accidental trauma

PA Culotta, JE Crowe, QA Tran, JY Jones… - Pediatric …, 2017 - Springer
Background Young children with suspected abusive head trauma often receive skull
radiographs to evaluate for fractures as well as computed tomography (CT) of the head to assess …

Structure and dynamics of GPCRs in lipid membranes: physical principles and experimental approaches

AJY Jones, F Gabriel, A Tandale, D Nietlispach - Molecules, 2020 - mdpi.com
Over the past decade, the vast amount of information generated through structural and
biophysical studies of GPCRs has provided unprecedented mechanistic insight into the complex …

Increased risk of pseudoprogression among pediatric low-grade glioma patients treated with proton versus photon radiotherapy

EB Ludmir, A Mahajan, AC Paulino, JY Jones… - Neuro …, 2019 - academic.oup.com
Background Pseudoprogression (PsP) is a recognized phenomenon after radiotherapy (RT)
for high-grade glioma but is poorly characterized for low-grade glioma (LGG). We sought to …