Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies

…, AA Konstas, B Bateman, GA Ortolano, J Pile-Spellman - Neuroradiology, 2007 - Springer
Introduction Restoration of blood flow following ischemic stroke can be achieved by means
of thrombolysis or mechanical recanalization. However, for some patients, reperfusion may …

Surgical management of unruptured intracranial aneurysms

RA Solomon, ME Fink, J Pile-Spellman - Journal of neurosurgery, 1994 - thejns.org
✓ The surgical management of patients with unruptured intracranial aneurysms continues to
be controversial. The criteria for withholding treatment or choosing between endovascular …

Intraarterially administered verapamil as adjunct therapy for cerebral vasospasm: safety and 2-year experience

…, H Duong, J Pile-Spellman - American Journal …, 2002 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Despite the widespread use of angioplasty, adjunct
chemical therapy is often needed to treat patients with cerebral vasospasm. In this study, we …

Risk of spontaneous haemorrhage after diagnosis of cerebral arteriovenous malformation

…, RR Sciacca, A Osipov, J Pile-Spellman… - The Lancet, 1997 - thelancet.com
John Pile-Spellman initiated the reaserch, participated in data collection particularly on
morphological aspects of AVM, discussed core ideas, and edited the paper. Lotfi Hacein-Bey …

MERCI 1: a phase 1 study of Mechanical Embolus Removal in Cerebral Ischemia

…, T Grobelny, CS Kidwell, R Jahan, J Pile-Spellman… - Stroke, 2004 - Am Heart Assoc
Background and Purpose— To report the result of the Mechanical Embolus Removal in
Cerebral Ischemia (MERCI) 1 study, a phase 1 trial to evaluate the safety and efficacy of …

Complications of modern diagnostic cerebral angiography in an academic medical center

…, V Cox, L Silverberg, S Mangla, J Pile-Spellman - Journal of Vascular and …, 2009 - Elsevier
PURPOSE: Catheter cerebral angiography and noninvasive cerebral imaging have steadily
improved in the past several decades. Now, catheter angiography is frequently reserved for …

Morbidity of intracranial hemorrhage in patients with cerebral arteriovenous malformation

…, JP Mohr, HC Koennecke, A Osipov, J Pile-Spellman… - Stroke, 1998 - Am Heart Assoc
Background and Purpose—Decisions on invasive arteriovenous malformation (AVM) treatment
are currently based on natural-course risk estimates of AVM bleeding and assumptions …

The influence of hemodynamic and anatomic factors on hemorrhage from cerebral arteriovenous malformations

A Kader, WL Young, J Pile-Spellman, H Mast… - …, 1994 - journals.lww.com
THE PHYSIOLOGICAL AND anatomical aberrations that result in hemorrhage from cerebral
arteriovenous malformations (AVMs) remain unclear. In an attempt to clarify which …

The epidemiology of brain arteriovenous malformations

MF Berman, RR Sciacca, J Pile-Spellman, C Stapf… - …, 2000 - journals.lww.com
OBJECTIVE: Common estimates of the prevalence rate for pial arteriovenous malformations
(AVMs) of the brain vary widely, and their accuracy is questionable. Our objective was to …

Feeding artery pressure and venous drainage pattern are primary determinants of hemorrhage from cerebral arteriovenous malformations

…, A Hartmann, S Joshi, JP Mohr, J Pile-Spellman - Stroke, 1998 - Am Heart Assoc
Purpose—The purpose of this study was to define the influence of feeding mean arterial
pressure (FMAP) in conjunction with other morphological or clinical risk factors in determining …