Mechanisms of stroke in COVID-19

JD Spence, GR De Freitas, LC Pettigrew, H Ay… - Cerebrovascular …, 2020 - karger.com
In this Commentary, we address mechanisms of stroke in patients with coronavirus disease
2019 (COVID-19) due to infection with the severe acute respiratory syndrome coronavirus-2 (…

Hemidystonia: a report of 22 patients and a review of the literature.

LC Pettigrew, J Jankovic - Journal of Neurology, Neurosurgery & …, 1985 - jnnp.bmj.com
Hemidystonia defined as involuntary, sustained posturing of the unilateral arm, leg, and
face was studied in 12 male and 10 female patients. Hemidystonia was caused by …

Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention …

…, LE Chambless, JD Spence, LC Pettigrew… - Jama, 2004 - jamanetwork.com
ContextIn observational studies, elevated plasma total homocysteine levels have been
positively associated with ischemic stroke risk. However the utility of homocysteine-lowering …

[HTML][HTML] A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke

…, JP Kistler, GW Albers, LC Pettigrew… - … England Journal of …, 2001 - Mass Medical Soc
Background Despite the use of antiplatelet agents, usually aspirin, in patients who have had
an ischemic stroke, there is still a substantial rate of recurrence. Therefore, we investigated …

Stroke care during the COVID-19 pandemic: international expert panel review

…, D Pastori, ST Pendlebury, LC Pettigrew… - Cerebrovascular …, 2021 - karger.com
Background: Coronavirus disease 2019 (COVID-19) has placed a tremendous strain on
healthcare services. This study, prepared by a large international panel of stroke experts, …

Estradiol protects against ischemic injury

DB Dubal, ML Kashon, LC Pettigrew… - Journal of Cerebral …, 1998 - journals.sagepub.com
Clinical studies demonstrate that estrogen replacement therapy in postmenopausal women
may enhance cognitive function and reduce neurodegeneration associated with Alzheimer's …

A randomized dose-response trial of citicoline in acute ischemic stroke patients

WM Clark, SJ Warach, LC Pettigrew, RE Gammans… - Neurology, 1997 - AAN Enterprises
Citicoline (CDP-choline) is a key intermediary in the biosynthesis of phosphatidylcholine, an
important component of the neural cell membrane. It has been shown to produce beneficial …

Minocycline to improve neurologic outcome in stroke (MINOS) a dose-finding study

…, JL Waller, FT Nichols, DJ Edwards, LC Pettigrew… - Stroke, 2010 - Am Heart Assoc
Background and Purpose—Minocycline is a promising anti-inflammatory and protease inhibitor
that is effective in multiple preclinical stroke models. We conducted an early phase trial …

Safety and tolerability of the glutamate antagonist CGS 19755 (selfotel) in patients with acute ischemic stroke: results of a phase IIa randomized trial

J Grotta, W Clark, B Coull, LC Pettigrew, B Mackay… - Stroke, 1995 - Am Heart Assoc
Background and Purpose CGS 19755 is a competitive N-methyl-d-aspartate (NMDA) receptor
antagonist that limits neuronal damage in animal stroke models. The objectives of this …

Secreted forms of β‐amyloid precursor protein protect against ischemic brain injury

VL Smith‐Swintosky, LC Pettigrew… - Journal of …, 1994 - Wiley Online Library
The β‐amyloid precursor protein (βAPP) is the source of the amyloid β‐peptide that accumulates
in the brain in Alzheimer's disease. A major processing pathway for βAPP involves an …