The First Key Symposium was held in Stockholm, Sweden, 2–5 September 2003. The aim
of the symposium was to integrate clinical and epidemiological perspectives on the topic of …

Mild cognitive impairment is a syndrome defined as cognitive decline greater than expected
for an individual's age and education level but that does not interfere notably with activities …

Alzheimer's disease is the most common cause of dementia. Research advances have enabled
detailed understanding of the molecular pathogenesis of the hallmarks of the disease—…

Neuropathology studies show that patients with mild cognitive impairment (MCI) and
Alzheimer's disease typically have lesions of the entorhinal cortex (EC), hippocampus (Hip), and …

… Manuel de LEON … We denote by C*(M) the set of all differentiable functions on M.
Obviously, all the definitions rest valid for mappings and functions defined on open sets of M. …

We used CT and MR to examine the frequency of occurrence of hippocampal formation atrophy
(HA) in a research clinic population of 130 normal elderly, 72 nondemented patients with …

Elevated glucocorticoid levels produce hippocampal dysfunction and correlate with individual
deficits in spatial learning in aged rats. Previously we related persistent cortisol increases …

Cognitive decline associated with old age and consistent with the diagnosis of primary
degenerative dementia is a unique clinical syndrome with characteristic phenomena and …

There is increasing evidence that subjective cognitive decline (SCD) in individuals with
unimpaired performance on cognitive tests may represent the first symptomatic manifestation of …

Importance Cerebral amyloid-β aggregation is an early pathological event in Alzheimer
disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid …