Antigen-specific CD8 T cells are central to the control of chronic infections and cancer, but
persistent antigen stimulation results in T cell exhaustion. Exhausted CD8 T cells have …

The spectral energy gap is an important signature that defines states of quantum matter:
insulators, density waves and superconductors have very different gap structures. The …

Alzheimer's disease (AD) and Lewy body disease (LBD) are the most common causes of
dementia in the elderly population. Previous studies have shown that cognitive alterations in …

Chronic viral infections are characterized by a state of CD8 + T-cell dysfunction that is associated
with expression of the programmed cell death 1 (PD-1) inhibitory receptor 1 , 2 , 3 , 4 . …

We characterized β-synuclein, the non-amyloidogenic homolog of α-synuclein, as an
inhibitor of aggregation of α-synuclein, a molecule implicated in Parkinson's disease. For this, …

This report shows that highly self-reactive T cells produced in mice as a result of genetically
altered thymic T cell selection spontaneously differentiate into interleukin (IL)-17–secreting …

… in these seedlings cultured even at 20 µmol photons m -2 s -1 (F v /F m = 0.696 ± 0.02 (±
sd), where F m = maximum fluorescence level in the dark, and F v = F m - F o , where F o is the …

Background It is a challenge to identify patients who, after undergoing potentially curative
treatment for hepatocellular carcinoma, are at greatest risk for recurrence. Such high-risk …

… To represent the notion of these costs in this analysis, assume the value per unit of
specific human capital in the firm to be (m + q), where m is now the expected value of the real …

The nature of the pseudogap phase of cuprate high-temperature superconductors is a major
unsolved problem in condensed matter physics. We studied the commencement of the …