PURPOSE: The purpose of this study was to evaluate the utility of transcatheter thrombolytic
therapy in 20 patients with acute or subacute (symptoms <40 days) portal and/or mesenteric …

An analysis of the activity of compounds tested in pre-clinical in vivo and in vitro assays by
the National Cancer Institute's Developmental Therapeutics Program was performed. For 39 …

Advancement of potential anti-cancer agents from “discovery” in an in vitro screen to pre-clinical
development requires a demonstration of in vivo efficacy in one or more animal models …

Phase 0 clinical trials, developed in response to the United States Food and Drug Administration
(FDA)'s recent exploratory Investigational New Drug (IND) guidance, are intended to …

Phase 0 trials are designed primarily to evaluate the pharmacodynamic and/or pharmacokinetic
properties of selected investigational agents before initiating more traditional phase I …

A series of novel curcumin analogs were synthesized and screened for anti-cancer and anti-angiogenesis
activities at Emory University and at the National Cancer Institute (NCI). These …

The Food and Drug Administration (FDA) recently introduced the Exploratory Investigational
New Drug Guidance to expedite the clinical evaluation of new therapeutic and imaging …

Background Xenograft samples used to test anti-cancer drug efficacies and toxicities in vivo
contain an unknown mix of mouse and human cells. Evaluation of drug activity can be …

… Another unanticipated finding was that many critical regulators of M phase of the cell
cycle had rapidly degraded mRNAs. In light of the short duration of M phase, these labile M-phase …

A series of 23 Amaryllidaceae isoquinoline alkaloids and related synthetic analogues were
isolated or synthesized and subsequently evaluated in cell culture against the RNA-…