Mucopolysaccharidosis type II (MPS II; Hunter syndrome) is a rare X-linked recessive
disease caused by deficiency of the lysosomal enzyme iduronate-2-sulphatase, leading to …

The brain is in many ways an immunologically and pharmacologically privileged site. The
blood–brain barrier (BBB) of the cerebrovascular endothelium and its participation in the …

The mucopolysaccharidoses (MPSs) are inherited lysosomal storage disorders caused by
the absence of functional enzymes that contribute to the degradation of glycosaminoglycans (…

The direct CP violation parameter Re(ϵ′/ϵ) has been measured from the decay rates of
neutral kaons into two pions using the NA48 detector at the CERN SPS. The 2001 running …

A sample of 1.69 × 10 7 fully reconstructed π 0 → γ e + e − decay candidates collected by the
NA48/2 experiment at CERN in 2003–2004 is analyzed to search for the dark photon ( A ′ …

… 5), the vacuum chamber containing the two beams opened up into a cylindrical tank of
total length 89 m and inner diameter 1.92 m increasing in two steps up to 2.40 m at the end …

OBJECTIVE: The objective of this Phase 3 study was to confirm the efficacy and safety of
recombinant human arylsulfatase B (rhASB) treatment of mucopolysaccharidosis type VI (MPS …

IL-33 is a novel member of the IL-1 family and ligand for the IL-1 receptor-related protein,
ST2. Recent evidence suggests that the IL-33/ST2 axis plays a critical role in several …

The main aim of the present study was to clarify whether different types of grasping may affect
the transport component of prehension movements. To this purpose two experiments were …

Background Lysosomal acid lipase is an essential lipid-metabolizing enzyme that breaks
down endocytosed lipid particles and regulates lipid metabolism. We conducted a phase 3 trial …