In this review we summarize the clinical and genetic aspects of Angelman syndrome (AS),
its molecular and cellular underpinnings, and current treatment strategies. AS is a …

Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular
entities focused on ‘small’ chemical compounds. The molecular entities in question are either …

In January 2017, the International Seabed Authority released a discussion paper on the
development of Environmental Regulations for deep-sea mining (DSM) within the Area Beyond …

A cohort of genes associated with embryonic stem (ES) cell behaviour, including NANOG,
are expressed in a number of human cancers. They form an ES‐like signature we first …

Macroautophagy (herein referred to as autophagy) is a complex catabolic process characterized
by the formation of double-membrane vesicles called autophagosomes. During this …

Melanoma is one of the most aggressive cancers, and its incidence is increasing. These
tumors derive from the melanocyte lineage and remain incurable after metastasis. Here we …

Human colon cancers often start as benign adenomas through loss of APC, leading to enhanced
βCATENIN (βCAT)/TCF function. These early lesions are efficiently managed but often …

Microalgae, with their high lipid content, are a promising feedstock for renewable fuels.
Traditionally, human and environmentally toxic solvents have been used to extract these lipids, …

The Rimicaris exoculata dominates the megafauna of some of the Mid Atlantic ridge
hydrothermal vent sites. This species harbors a rich community of bacterial epibionts inside its gill …

AMPK is a central regulator of metabolism and autophagy. Here we show how lysosomal
damage activates AMPK. This occurs via a hitherto unrecognized signal transduction system …