User profiles for M.D. Chan

Michael D. Chan, MD

Professor of Radiation Oncology
Verified email at wakehealth.edu
Cited by 8579

Radiation-induced brain injury: a review

…, AM Peiffer, EG Shaw, KT Wheeler, MD Chan - Frontiers in …, 2012 - frontiersin.org
Approximately 100,000 primary and metastatic brain tumor patients/year in the US survive
long enough (>6 months) to experience radiation-induced brain injury. Prior to 1970, the …

Initial SRS for patients with 5 to 15 brain metastases: results of a multi-institutional experience

…, S Chao, A Attia, DN Ayala-Peacock, MD Chan - International Journal of …, 2019 - Elsevier
Purpose Several studies evaluating stereotactic radiosurgery (SRS) for patients with >4 brain
metastases (BM) demonstrated similar outcomes after treatment of 1, 2 to 4, and 5 to 15 BM…

Atypical teratoid/rhabdoid tumor: the controversy behind radiation therapy

SE Squire, MD Chan, KJ Marcus - Journal of neuro-oncology, 2007 - Springer
To date, approximately 200 cases of atypical teratoid/rhabdoid tumor (AT/RT) of the central
nervous system have been described in the literature. This CNS tumor tends to present at an …

Loss of XIST in breast cancer activates MSN-c-Met and reprograms microglia via exosomal miRNA to promote brain metastasis

…, S Sanders, G Jin, R Singh, PA Vidi, A Tyagi, MD Chan… - Cancer research, 2018 - AACR
Up to 30% of patients with metastatic breast cancer eventually develop brain metastasis, yet
the pathologic mechanism behind this development remains poorly understood. Here, we …

[HTML][HTML] Donepezil for irradiated brain tumor survivors: a phase III randomized placebo-controlled clinical trial

…, A Peiffer, MM Naughton, MD Chan… - Journal of Clinical …, 2015 - ncbi.nlm.nih.gov
… Participants were enrolled at two academic medical centers (Wake Forest University
Baptist Medical Center and MD Anderson Cancer Center), 21 community clinical oncology …

Evaluation of first-line radiosurgery vs whole-brain radiotherapy for small cell lung cancer brain metastases: the FIRE-SCLC cohort study

…, H Yang, AA Aizer, DN Cagney, MD Chan… - JAMA …, 2020 - jamanetwork.com
… Dr Chan reported receiving other from Monteris and Elekta outside the submitted work.
Dr Kondziolka reported receiving grants from Brainlab outside the submitted work. Dr Seto …

MRI volumes of the hippocampus and amygdala in adults with Down's syndrome with and without dementia

…, MB Pulsifer, PE Barta, MD Chan… - American Journal of …, 1999 - Am Psychiatric Assoc
OBJECTIVE: This study sought to determine whether volumes of the hippocampus and
amygdala are disproportionately smaller in subjects with Down’s syndrome than in normal …

Cavity-directed radiosurgery as adjuvant therapy after resection of a brain metastasis

CA Jensen, MD Chan, TP McCoy, JD Bourland… - Journal of …, 2011 - thejns.org
… Acquisition of data: Chan, Jensen. Analysis and interpretation of data: Chan, Jensen, McCoy,
Ellis, Tatter. Drafting the article: Chan, Jensen, McCoy, Tatter. Critically revising the article: …

Roles of the cyclooxygenase 2 matrix metalloproteinase 1 pathway in brain metastasis of breast cancer

…, F Xing, Y Zhang, S Sharma, Y Liu, MD Chan… - Journal of Biological …, 2015 - ASBMB
Background: Mechanism of brain metastasis of breast cancer is poorly understood. Results:
Inflammatory factors secreted from cancer cells degrade tight junction of BBB and stimulate …

Activation of the c-Met pathway mobilizes an inflammatory network in the brain microenvironment to promote brain metastasis of breast cancer

F Xing, Y Liu, S Sharma, K Wu, MD Chan, HW Lo… - Cancer research, 2016 - AACR
Brain metastasis is one of the chief causes of mortality in breast cancer patients, but the
mechanisms that drive this process remain poorly understood. Here, we report that brain …