The description of a so-called cytokine storm in patients with COVID-19 has prompted
consideration of anti-cytokine therapies, particularly interleukin-6 antagonists. However, direct …

… between Treg activity in mouse model systems and the observations in human helminth
infections led us to investigate the role of Tregs in experimental nematode infections (Taylor M, …

The division of medulloblastoma into different subgroups by microarray expression profiling
has dramatically changed our perspective of this malignant childhood brain tumour. Now, …

Accurate pathological diagnosis is crucial for optimal management of patients with cancer.
For the approximately 100 known tumour types of the central nervous system, standardization …

Medulloblastoma, a small blue cell malignancy of the cerebellum, is a major cause of morbidity
and mortality in pediatric oncology. Current mechanisms for clinical prognostication and …

Glioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays considerable
heterogeneity. We have recently identified recurrent H3F3A mutations affecting two …

Lentiviral delivery of glial cell line–derived neurotrophic factor (lenti-GDNF) was tested for
its trophic effects upon degenerating nigrostriatal neurons in nonhuman primate models of …

Purpose Recent genomic approaches have suggested the existence of multiple distinct
subtypes of medulloblastoma. We studied a large cohort of medulloblastomas to determine how …

Medulloblastoma is the most common malignant brain tumor in childhood. Molecular studies
from several groups around the world demonstrated that medulloblastoma is not one …

The sonic hedgehog (SHH) signaling pathway directs the embryonic development of diverse
organisms and is disrupted in a variety of malignancies. Pathway activation is triggered by …