Studies of the broader autism phenotype, and of subtle changes in autism symptoms over
time, have been compromised by a lack of established quantitative assessment tools. The …

Background Progressive multifocal leukoencephalopathy (PML) is an opportunistic brain
infection that is caused by the JC virus and is typically fatal unless immune function can be …

PURPOSE: To assess the impact of aging on the radiation response in the adult rat brain.
METHODS AND MATERIALS: Male rats 8, 18, or 28 months of age received a single 10-Gy …

OBJECTIVE: Postmortem and neuroimaging studies of schizophrenia have reported deficits
in the volume of the thalamus and its component nuclei. However, the pattern of shape …

BACKGROUND AND PURPOSE: MR imaging–pathologic studies have reported that paramagnetic
rims on 7T susceptibility-based MR imaging identify, in vivo, the subset of MS lesions …

Objective The diagnosis of multiple sclerosis ( MS ) presently relies on radiographic
assessments of imperfect specificity. Recent data using T2* methodology for the detection of the “…

BACKGROUND Cytotoxic T lymphocyte antigen 4 (CTLA4) is essential for immune
homeostasis. Genetic mutations causing haploinsufficiency (CTLA4h) lead to a phenotypically …

Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system.
Although it has been extensively studied, the proximate trigger of the immune response …

Importance Subclinical inflammatory demyelination and neurodegeneration often precede
symptom onset in multiple sclerosis (MS). Objective To investigate the prevalence of brain …

Pathogens, particularly human herpesviruses (HHVs), are implicated as triggers of disease
onset/progression in multiple sclerosis (MS) and other neuroinflammatory disorders. However…