Radiomics of pediatric low-grade gliomas: toward a pretherapeutic differentiation of BRAF-mutated and BRAF-fused tumors
BACKGROUND AND PURPOSE: B-Raf proto-oncogene, serine/threonine kinase (BRAF)
status has important implications for prognosis and therapy of pediatric low-grade gliomas …
status has important implications for prognosis and therapy of pediatric low-grade gliomas …
Noninvasive molecular subtyping of pediatric low-grade glioma with self-supervised transfer learning
Purpose To develop and externally test a scan-to-prediction deep learning pipeline for
noninvasive, MRI-based BRAF mutational status classification for pediatric low-grade …
noninvasive, MRI-based BRAF mutational status classification for pediatric low-grade …
Outcomes of BRAF V600E pediatric gliomas treated with targeted BRAF inhibition
PURPOSE Children with pediatric gliomas harboring a BRAF V600E mutation have poor
outcomes with current chemoradiotherapy strategies. Our aim was to study the role of …
outcomes with current chemoradiotherapy strategies. Our aim was to study the role of …
Interplay among BRAF, p16, p53, and MIB1 in pediatric low-grade gliomas
C Horbinski, MN Nikiforova, JM Hagenkord… - Neuro …, 2012 - academic.oup.com
Abstract BRAF rearrangements and BRAF V600E point mutations are recurring events in
pediatric low-grade gliomas. However, their clinical significance, including possible …
pediatric low-grade gliomas. However, their clinical significance, including possible …
[HTML][HTML] Unsupervised machine learning using K-means identifies radiomic subgroups of pediatric low-grade gliomas that correlate with key molecular markers
Introduction Despite advancements in molecular and histopathologic characterization of
pediatric low-grade gliomas (pLGGs), there remains significant phenotypic heterogeneity …
pediatric low-grade gliomas (pLGGs), there remains significant phenotypic heterogeneity …
[HTML][HTML] Current understanding of BRAF alterations in diagnosis, prognosis, and therapeutic targeting in pediatric low-grade gliomas
CL Penman, C Faulkner, SP Lowis, KM Kurian - Frontiers in oncology, 2015 - frontiersin.org
The mitogen-activated protein kinase (MAPK) pathway is known to play a key role in the
initiation and maintenance of many tumors as well as normal development. This often occurs …
initiation and maintenance of many tumors as well as normal development. This often occurs …
To BRAF or Not to BRAF: Is That Even a Question Anymore?
C Horbinski - Journal of Neuropathology & Experimental …, 2013 - academic.oup.com
Alterations in BRAF have been discovered in most pediatric low-grade gliomas. Because the
field has moved quickly during the past few years, there is not yet widespread awareness …
field has moved quickly during the past few years, there is not yet widespread awareness …
Upfront molecular targeted therapy for the treatment of BRAF-mutant pediatric high-grade glioma
Background The prognosis for patients with pediatric high-grade glioma (pHGG) is poor
despite aggressive multimodal therapy. Objective responses to targeted therapy with BRAF …
despite aggressive multimodal therapy. Objective responses to targeted therapy with BRAF …
Clinical, radiological and genomic features and targeted therapy in BRAF V600E mutant adult glioblastoma
MJ Lim-Fat, KW Song, JB Iorgulescu… - Journal of Neuro …, 2021 - Springer
Purpose Although uncommon, detection of BRAF V600E mutations in adult patients with
glioblastoma has become increasingly relevant given the widespread application of …
glioblastoma has become increasingly relevant given the widespread application of …
[HTML][HTML] BRAF mutations may identify a clinically distinct subset of glioblastoma
SN McNulty, KE Schwetye, C Ferguson, CE Storer… - Scientific reports, 2021 - nature.com
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. Prior
studies examining the mutational landscape of GBM revealed recurrent alterations in genes …
studies examining the mutational landscape of GBM revealed recurrent alterations in genes …
