Objective: The major form of magnetic resonance imaging–defined white matter injury (WMI)
comprises diffuse lesions where the burden of small necrotic foci (microscopic necrosis) is …

Importance Cognitive impairment and dementia, including Alzheimer disease (AD), are
common within the aging population, yet the factors that render the aging brain vulnerable to …

Clinical and pathologicals evidence of subcortical central nervous system (CNS) damage is
observed commonly in patients with human immunodeficiency virus (HIV) encephalitis. …

Background Slowed clearance of amyloid β (Aβ) is believed to underlie the development of
Aβ plaques that characterize Alzheimer’s disease (AD). Aβ is cleared in part by the …

The P450 eicosanoids epoxyeicosatrienoic acids (EETs) are produced in brain and perform
important biological functions, including protection from ischemic injury. The beneficial effect …

Zika virus (ZIKV) infection during pregnancy leads to an increased risk of fetal growth restriction
and fetal central nervous system malformations, which are outcomes broadly referred to …

Pantothenate kinase-associated neurodegeneration is a form of neurodegeneration with brain
iron accumulation, characterized by a progressive movement disorder and prominent iron …

Stillbirth is a major obstetric complication, with 3.2 million stillbirths worldwide and 26,000
stillbirths in the United States every year. The Eunice Kennedy Shriver National Institute of …

A primary goal of investigations into the organization of human cerebral cortex is to
determine the functional specificity of architectonic regions. This includes the correlation of …

The calcium-permeable transient receptor potential M2 (TRPM2) ion channel is activated
following oxidative stress and has been implicated in ischemic damage; however, little …