Background Autosomal dominant polycystic kidney disease (ADPKD) is a slowly progressive
hereditary disorder that usually leads to end-stage renal disease. Although the underlying …

Purpose: Regorafenib is a novel oral multikinase inhibitor of angiogenic (VEGFR1-3, TIE2),
stromal (PDGFR-β, FGFR), and oncogenic kinases (KIT, RET, and RAF). This first-in-man, …

BACKGROUND: Glutamatergic dysfunction has been implicated in the pathophysiology of
schizophrenia. However, so far there is limited direct evidence of altered in vivo glutamate …

Lhermitte-Duclos disease (LDD) is a rare cerebellar lesion with features of both malformation
and benign neoplasm. However, the fundamental nature of the entity, its pathogenesis, …

BACKGROUND: Executive dysfunction is a core feature of schizophrenia. The neurochemical
and structural changes associated with this deficit are, however, largely unclear. This …

Glutamatergic dysfunction has been implicated in the pathophysiology of schizophrenia. In
this study we performed absolute-quantification short-echo magnetic resonance …

Purpose: PTK787/ZK 222584 (PTK/ZK), an orally active inhibitor of vascular endothelial
growth factor (VEGF) receptor tyrosine kinases, inhibits VEGF-mediated angiogenesis. The …

Background To report the nonrandomized first-in-human phase I trial of PRS-050, a novel,
rationally engineered Anticalin based on human tear lipocalin that targets and antagonizes …

Background and Purpose Hypoxia is an essential metabolic marker that determines chemo-
and radiation resistance in head-and-neck squamous cell carcinoma (HNSCC) patients. …

Purpose To demonstrate the feasibility of an algorithm for MRI whole‐body quantification of
internal and subcutaneous fat and quantitative comparison of total adipose tissue to air …