Abstract Characterization of the genetic landscape of Alzheimer’s disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

Background Familial hemiplegic migraine is an autosomal dominant severe subtype of
migraine with aura characterised by some degree of hemiparesis during the attacks. So far, …

Small vessel disease is a disorder of cerebral microvessels that causes white matter
hyperintensities and several other common abnormalities (eg, recent small subcortical infarcts and …

Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous
disease with multiple contributors to its pathophysiology, including vascular dysfunction…

Cerebrovascular disease typically manifests with stroke, cognitive impairment, or both.
Vascular cognitive impairment refers to all forms of cognitive disorder associated with …

Background and Purpose— Ischemic stroke (IS) and coronary artery disease (CAD) share
several risk factors and each has a substantial heritability. We conducted a genome-wide …

Background Regularly updated data on stroke and its pathological types, including data on
their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are …

We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD)
involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 …

Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features
seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter …

Ischaemic stroke is a heterogeneous multifactorial disorder. Epidemiological data provide
substantial evidence for a genetic component to the disease, but the extent of predisposition is …