Background Among patients with a proximal vessel occlusion in the anterior circulation, 60
to 80% of patients die within 90 days after stroke onset or do not regain functional …

Background In 2015, five randomised trials showed efficacy of endovascular thrombectomy
over standard medical care in patients with acute ischaemic stroke caused by occlusion of …

Background Transcranial Doppler ultrasonography that is aimed at residual obstructive
intracranial blood flow may help expose thrombi to tissue plasminogen activator (t-PA). Our …

Background Nerinetide, an eicosapeptide that interferes with post-synaptic density protein
95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia-reperfusion. …

Background Neuroprotection with NA-1 (Tat-NR2B9c), an inhibitor of postsynaptic density-95
protein, has been shown in a primate model of stroke. We assessed whether NA-1 could …

Background Carotid-artery stenting and carotid endarterectomy are both options for treating
carotid-artery stenosis, an important cause of stroke. Methods We randomly assigned …

Background Trials of the efficacy and safety of endovascular thrombectomy in patients with
large ischemic strokes have been carried out in limited populations. Methods We performed a …

Background Endovascular therapy is increasingly used after the administration of intravenous
tissue plasminogen activator (t-PA) for patients with moderate-to-severe acute ischemic …

Background: The risk of stroke is elevated in the first 48 hours after TIA. Previous prognostic
models suggest that diabetes mellitus, age, and clinical symptomatology predict stroke. The …

Importance Endovascular thrombectomy with second-generation devices is beneficial for
patients with ischemic stroke due to intracranial large-vessel occlusions. Delineation of the …